细胞焦亡在新生儿缺氧缺血性脑病中的研究进展

doi:10.20047/j.issn1673-7210.2023.18.12

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摘要新生儿缺氧缺血性脑病（HIE）是新生儿最常见的神经系统病变之一，具有致残率、死亡率高的特点，且目前临床上尚无特异性治疗手段。大量研究数据表明，炎症的激活和扩散是新生儿HIE发生发展的主要原因，而细胞焦亡作为近年新发现的一种炎症细胞死亡模式，受到人们的广泛关注。关于细胞焦亡与新生儿HIE的研究逐年增多，大量的数据表明细胞焦亡是新生儿HIE的重要致损机制。本文围绕细胞焦亡和新生儿HIE的研究进展进行综述。

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	黄润芝1　　曹长青2　　李宇宁2

关键词 ：新生儿, 缺氧缺血性脑病, 细胞焦亡, 炎症

Abstract：Hypoxic-ischemic encephalopathy （HIE） is the leading cause of disability and death in neonatal, which has been a major health concern worldwide. At present, there is still a lack of satisfactory treatment for HIE, which is a great threat to children’s health and quality of life. Mutiple researches have shown that the activation and diffusion of inflammation is the main reason for the occurrence and development of HIE. Pyroptosis is a relatively recently described mechanism of inflammatory cell death that is closely related to HIE. The study on pyroptosis and HIE is increasing year by year. This paper summarizes the pivotal role of pyroptosis in HIE and analysis the related mechanisms to provide a basis for future research.

Key words： Neonatal Hypoxic-ischemic encephalopathy Pyroptosis Inflammation

基金资助:甘肃省教育厅科技创新基金项目（2022B-024）。

通讯作者: 李宇宁（1962-），男，教授，主任医师；研究方向：儿童肾脏疾病。

作者简介: 黄润芝（1996-），女，兰州大学第一临床医学院2020级儿科学专业在读硕士研究生；研究方向：儿童神经疾病。

引用本文:

黄润芝1　　曹长青2　　李宇宁2. 细胞焦亡在新生儿缺氧缺血性脑病中的研究进展[J]. 中国医药导报, 2023, 20(18): 56-60.
HUANG Runzhi1 CAO Changqing2 LI Yuning2. Research advances in the role of pyroptosis in neonatal hypoxic-ischemic encephalopathy. 中国医药导报, 2023, 20(18): 56-60.

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