Research progress on the role of mast cells in knee osteoarthritis in obese patients
LIU Gaoqing1 JIN Zhu1 LIU Xiaomeng2 WANG Lihe3
1.College of Orthopaedics and Traumatology, Henan University of Chinese Medicine, Henan Province, Zhengzhou 450000, China;
2.the First Clinical School, Henan University of Chinese Medicine, Henan Province, Zhengzhou 450000, China;
3.Department of Orthopaedics and Traumatology, the First Affiliated Hospital of Henan University of Chinese Medicine, Henan Province, Zhengzhou 450000, China
Abstract：Mast cells (MCs) are immune cells in human tissues, and obesity is one of the risk factors for knee osteoarthritis (KOA). MCs have important physiological and pathological effects in adipose tissue, and the two influence each other and play an important role in the progression of KOA in obese patients. In this paper, the activation of MCs, the obesity-induced inflammatory factors of KOA, the role of MCs in obese tissue, the influence of MCs-related mediators on KOA in obese patients, and the signaling pathways related to KOA in obese patients are summarized and analyzed, and the role of MCs in KOA in obese patients is summarized, in order to provide new ideas for the diagnosis, treatment, and prevention of KOA in obese patients, it may help in the search for prevention targets and therapeutic drug targets.
刘高卿1 金柱1 刘晓萌2 汪利合3. 肥大细胞在肥胖患者膝骨关节炎中的作用研究进展[J]. 中国医药导报, 2023, 20(18): 47-50.
LIU Gaoqing1 JIN Zhu1 LIU Xiaomeng2 WANG Lihe3. Research progress on the role of mast cells in knee osteoarthritis in obese patients. 中国医药导报, 2023, 20(18): 47-50.
[1] Primorac D，Molnar V，Rod E，et al. Knee Osteoarthritis：A Rev- iew of Pathogenesis and State-Of-The-Art Non-Operative Therapeutic Considerations [J]. Genes（Basel），2020，11（8）：854.
[2] 蒋磊，苏程，葛军，等.膝骨关节炎危险因素研究[J].医学信息，2020，33（15）15：30-33.
[3] Batushansky A，Zhu S，Komaravolu RK，et al. Fundamentals of OA. An initiative of Osteoarthritis and Cartilage. Obesity and metabolic factors in OA [J]. Osteoarthritis Cartilage，2022，30（4）：501-515.
[4] Elieh Ali Komi D，W?觟hrl S，Bielory L. Mast Cell Biology at Molecular Level：a Comprehensive Review [J]. Clin Rev Allergy Immunol，2020，58（3）：342-365.
[5] Ogasawara H，Noguchi M. Therapeutic Potential of MRGPRX2 Inhibitors on Mast Cells [J]. Cells，2021，10（11）：2906.
[6] Guerreiro VA，Carvalho D，Freitas P. Obesity，Adipose Tissue，and Inflammation Answered in Questions [J]. J Obes，2022，2022：2252516.
[7] Kawai T，Autieri MV，Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity [J]. Am J Physiol Cell Physiol，2021，320（3）：C375-C391.
[8] 杨放，陈泽铭，余盛，等.早期与晚期膝骨关节炎患者髌下脂肪垫脂肪组织相关炎症因子水平比较[J].现代实用医学，2021，33（7）：869-871.
[9] 齐睿娟，高源，齐云.肥大细胞在脂肪组织中的生理与病理作用[J].中国病理生理杂志，2021，37（1）：151-158.
[10] Duan L，Ma Y，Wang Y，et al. Infrapatellar fat pads participate in the development of knee osteoarthritis in obese patients via the activation of the NF-κB signaling pathway [J]. Int J Mol Med，2020，46（6）：2260-2270.
[11] Kruisbergen NNL，van Gemert Y，Blom AB，et al. Activation of circulating monocytes by low-density lipoprotein-a risk factor for osteoarthritis? [J]. Rheumatology（Oxford），2022，62（1）：42-51.
[12] Gurung P，Moussa K，Adams-Huet B，et al. Increased mast cell abundance in adipose tissue of metabolic syndrome：relevance to the proinflammatory state and increased adipose tissue fibrosis [J]. Am J Physiol Endocrinol Metab，2019，316（3）：E504-E509.
[13] Takata K，Uchida K，Takano S，et al. Possible Regulation of bFGF Expression by Mast Cells in Osteoarthritis Patients with Obesity：A Cross-Sectional Study [J]. Diabetes Metab Syndr Obes，2021，14：3291-3297.
[14] ■elechowska P，Brzezińska-B?覥aszczyk E，Wiktorska M，et al. Adipocytokines leptin and adiponectin function as mast cell activity modulators [J]. Immunology，2019，158（1）：3- 18.
[15] Elieh Ali Komi D，Shafaghat F，Christian M. Crosstalk Between Mast Cells and Adipocytes in Physiologic and Pathologic Conditions [J]. Clin Rev Allergy Immunol，2020，58（3）：388-400.
[16] Huang Z，Lan J，Gao X. Feprazone Mitigates IL-1β-Induced Cellular Senescence in Chondrocytes [J]. ACS Omega，2021，6（14）：9442-9448.
[17] 徐伟，廖冬发，吴畏，等.IL-1β通过诱导氧化应激促进软骨表层细胞衰老[J].免疫学杂志，2022，38（2）：164- 169.
[18] Woodell-May JE，Sommerfeld SD. Role of Inflammation and the Immune System in the Progression of Osteoarthritis [J]. J Orthop Res，2020，38（2）：253-257.
[19] Wang Q，Lepus CM，Raghu H，et al. IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis [J]. Elife，2019，8：e39905.
[20] Lü Q，Gou Y，Tian F，et al. Research progress on protease-activated receptor 2 in pathogenesis of osteoarthritis [J]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi，2017， 31（12）：1517-1522.
[21] 刘姣，曲崇正，谢平金，等.膝骨性关节炎模型大鼠接受推拿治疗后软骨Toll样受体4/髓样分化因子88信号转导通路的变化[J].中国组织工程研究，2019，23（19）：3019-3024.
[22] Kalaitzoglou E，Lopes EBP，Fu Y，et al. TLR4 Promotes and DAP12 Limits Obesity-Induced Osteoarthritis in Aged Female Mice [J]. JBMR Plus，2019，3（4）：e10079.
[23] 韦嵩，申茜茸，李晓昊，等.经筋微创松解术治疗膝骨关节炎对TLR4/MyD88/NF-κB信号转导通路的影响[J].中华中医药杂志，2018，33（10）：4637-4641.
[24] Shoukat M，Ullah R，Javaid M，et al. TLR-2 Germ Line Variants as a Risk for Obesity in Local Pakistani Population [J]. Arch Med Res，2022，53（4）：359-367.
[25] Xu X，Li N，Wu Y，et al. Zhuifeng tougu capsules inhibit the TLR4/MyD88/NF-κB signaling pathway and alleviate knee osteoarthritis：In vitro and in vivo experiments [J]. Front Pharmacol，2022，13：951860.
[26] Montagnoli C，Tiribuzi R，Crispoltoni L，et al. β-NGF and β-NGF receptor upregulation in blood and synovial fluid in osteoarthritis [J]. Biol Chem，2017，398（9）：1045-1054.
[27] Sousa-Valente J，Calvo L，Vacca V，et al. Role of TrkA signalling and mast cells in the initiation of osteoarthritis pain in the monoiodoacetate model [J]. Osteoarthritis Cartilage，2018，26（1）：84-94.
[28] Aso K，Shahtaheri SM，Hill R，et al. Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats [J]. Osteoarthritis Cartilage，2020，28（9）：1245-1254.
[29] Ali H. Emerging Roles for MAS-Related G Protein-Coupled Receptor-X2 in Host Defense Peptide，Opioid，and Neur-opeptide-Mediated Inflammatory Reactions [J]. Adv Immunol，2017，136：123-162.
[30] Green DP，Limjunyawong N，Gour N，et al. A Mast-Cell- Specific Receptor Mediates Neurogenic Inflammation and Pain [J]. Neuron，2019，101（3）：412-420.e3.
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