Metagenomic next-generation sequencing assisted diagnosis of Q fever bloodstream infection: a case report
CHEN Ping1 WU Wenbing2 GOU Hui3 REN Sichong4
1.Department of Pharmacy, Suining Central Hospital, Sichuan Province, Suining 629000, China;
2.Teaching and Research Section of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southwest Medical University, Sichuan Province, Luzhou 646000, China;
3.Department of Pharmacy, the Affiliated Hospital of Southwest Medical University, Sichuan Province, Luzhou 646000, China;
4.Department of Nephrology, the First Affiliated Hospital of Chengdu Medical College, Sichuan Province, Chengdu 610500, China
Abstract：Q fever bloodstream infection is an infection caused by Coxiella burnetii, because its clinical cases are rare, the clinical manifestations lack specificity and traditional detection methods are difficult to obtain its etiological evidence, resulting in the misdiagnosis rate is extremely high. In severe cases, multiple organs of the patient’s may be involved, which is life-threatening. Early diagnosis and precise treatment are still huge clinical challenges. Metagenomic next-generation sequencing has shown great potential in the diagnosis of rare pathogens infection, which makes the detection rate of Q fever pathogens continuously improve. This article reports one case of Q fever bloodstream infection successfully detected by metagenomic next-generation sequencing and timely treatment with reasonable antibiotics, the patient had good prognosis.
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