Abstract：Objective To investigate the risk factors of delayed bleeding after endoscopic mucosal resection (EMR) of colon polyps. Methods A total of 1 863 patients with colon polyp who were admitted to Beijing Anzhen Hospital Affiliated to Capital Medical University from January 2020 to December 2021 and received EMR treatment were selected and divided into hemorrhage group and non-hemorrhage group according to whether delayed hemorrhage occurred. Clinical data of patients were retrospectively collected to analyze the risk factors of delayed bleeding after colon polyp EMR surgery. Results Among the 1 863 patients, 36 had delayed hemorrhage (1.93%). The proportion of polyp diameter ≥1 cm, pedicled polyp and rectal polyp in bleeding group were higher than those in non-bleeding group, and the differences were statistically significant (P＜0.05). Multivariate logistic regression analysis showed that using antithrombotic drugs (OR [95%CI] =2.248 [1.054-4.793]), polyps in diameter ≥1 cm (OR [95%CI] =3.074 [1.338-7.061]), and rectal polyps (OR [95%CI] =5.577 [2.572-12.093]) were independent risk factors for delayed hemorrhage (P＜0.05). Conclusion Application of antithrombotic drugs, polyp size and polyp site are important risk factors for delayed bleeding after EMR surgery. Active and effective treatment should be carried out for high-risk patients in clinical practice to reduce the occurrence of delayed bleeding.
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