Comparison of clinical effect and dosimetry between synchronous and sequential tumor bed complementary radiotherapy after breast conserving surgery for breast cancer
LU Feng ZHANG Fei LI Taiping
Department of Radiotherapy, Fuyang Tumor Hospital, Anhui Province, Fuyang 236000, China
Abstract：Objective To study the clinical effect and dosimetry comparison between synchronous supplement of tumor bed in whole breast and sequential tumor bed supplementation in whole breast radiotherapy after breast conserving surgery for breast cancer. Methods Seventy-four patients with breast cancer in Department of Radiotherapy, Fuyang Tumor Hospital from January 2017 to April 2021 were selected and treated with breast conserving surgery for breast cancer. After surgery, they were divided into sequential group and synchronous group according to the random number table method, with 37 cases in each group. The sequential group received sequential tumor bed complementary radiotherapy, and the synchronous group received synchronous tumor bed complementary radiotherapy. The clinical effects, target dose of tumor bed dose, radiation dose endangering organs, and adverse radiation reactions were compared between the two groups. Results There was no significant difference in clinical effect between the two groups (P＞0.05). The average dose and maximum dose of tumor bed addition planned target area in synchronous group were lower than those in sequential group, and the differences were statistically significant (P＜0.05). The maximum doses of heart V30, lung V20, and spinal cord in the synchronous group were lower than those in the sequential group, and the differences were statistically significant (P＜0.05). The incidence of radiation pneumonia in the synchronous group was lower than that in the sequential group, and the difference was statistically significant (P＜0.05). Conclusion Compared with sequential tumor bed complementary radiotherapy, synchronous tumor bed complementary radiotherapy after breast conserving surgery for breast cancer can reduce the target dose, reduce the damage to the heart, lung, spinal cord, and other dangerous organs, and reduce the incidence of adverse radiation reactions.
卢峰 张飞 李太平. 乳腺癌保乳术后全乳放疗瘤床同步补量与序贯瘤床补量的临床效果及剂量学对比[J]. 中国医药导报, 2023, 20(17): 115-118.
LU Feng ZHANG Fei LI Taiping. Comparison of clinical effect and dosimetry between synchronous and sequential tumor bed complementary radiotherapy after breast conserving surgery for breast cancer. 中国医药导报, 2023, 20(17): 115-118.
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