血浆纤维蛋白原、前列腺特异性抗原密度与前列腺癌骨转移关系研究

doi:10.20047/j.issn1673-7210.2023.17.25

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摘要目的分析血浆纤维蛋白原（FIB）及前列腺特异性抗原密度（PSAD）水平与前列腺癌（PCa）骨转移的关系。方法回顾性收集江苏省徐州市中心医院2016年1月至2021年12月共148例初诊为PCa的患者资料，其中骨转移85例（57.4%）为骨转移组，无骨转移63例（42.6%）为无骨转移组。一般资料包括患者前列腺特异性抗原（PSA）水平、FIB水平、前列腺体积、骨转移情况、年龄、体重指数（BMI）、住院时长。分析FIB、PSAD与PCa骨转移的关系。结果两组FIB、PSAD水平比较，差异有统计学意义（P＜0.05）。FIB诊断PCa骨转移最佳截断点为3.840 g/L，灵敏度为54.1%，特异度为81.0%；PSAD预测PCa骨转移最佳截断点为0.393 ng/（ml·cm3），灵敏度为83.5%，特异度为63.5%。logistic回归分析示FIB、PSAD与PCa发生骨转移呈正相关(OR=2.180、2.251，P＜0.001)。结论 FIB、PSAD其水平与骨转移的发生呈正相关，在诊断PCa骨转移方面具有较高价值。

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	张鹏1　　李鑫钊2　　梁清3　　张治国3　　刘林3　　韩从辉3　　刘大闯1▲

关键词 ：血浆纤维蛋白原, 前列腺特异性抗原密度, 前列腺癌, 骨转移

Abstract：Objective To analyze the relationship between plasma fibrinogen (FIB) and prostate-specific antigen density (PSAD) levels and osseous metastasis of prostate cancer (PCa). Methods Data of 148 patients with PCa were retrospectively collected from Xuzhou Central Hospital of Jiangsu Province from January 2016 to December 2021. Among them, 85 (57.4%) patients with bone metastasis were the bone metastasis group, and 63 (42.6%) patients without bone metastasis were the no bone metastasis group. General information included prostate-specific antigen (PSA) levels, FIB levels, prostate volume, bone metastases, age, body mass index (BMI), and length of hospital stay. The relationship between FIB, PSAD, and PCa bone metastasis was analyzed. Results There were significant differences in FIB and PSAD levels between the two groups (P＜0.05). The optimal cut-off point was 3.840 g/L, sensitivity was 54.1%, and specificity was 81.0%. PSAD predicted that the optimal cut-off point of PCa was 0.393 ng/（ml·cm3）, the sensitivity was 83.5% and the specificity was 63.5%. Logistic regression analysis showed that FIB and PSAD were positively correlated with bone metastasis in PCa (OR=2.180, P＜0.001; OR=2.251, P＜0.001). Conclusion The levels of FIB and PSAD are positively correlated with the occurrence of osseous metastasis, which have high value in the diagnosis of osseous metastasis of prostate cancer.

Key words： Fibrinogen Prostate-specific antigen density Prostatecancer Osseous metastasis

基金资助:国家自然科学基金面上项目（81774089）；
徐州医科大学附属医院发展基金资助项目（XYFM2020001）。

通讯作者: ▲通讯作者

引用本文:

张鹏1　　李鑫钊2　　梁清3　　张治国3　　刘林3　　韩从辉3　　刘大闯1▲. 血浆纤维蛋白原、前列腺特异性抗原密度与前列腺癌骨转移关系研究[J]. 中国医药导报, 2023, 20(17): 111-114.
ZHANG Peng1 LI Xinzhao2 LIANG Qing3 ZHANG Zhiguo3 LIU Lin3 HAN Conghui3 LIU Dachuang1▲. Study on the relationship between plasma fibrinogen, prostate-specific antigen density， and osseous metastasis of prostate cancer. 中国医药导报, 2023, 20(17): 111-114.

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[1] Sung H，Ferlay J，Siegel RL，et al. Global Cancer Statistics 2020： GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries [J]. CA Cancer J Clin，2021，71（3）：209-249.
[2] Cao W，Chen HD，Yu YW，et al. Changing profiles of cancer burden worldwide and in China： a secondary analysis of the global cancer statistics 2020 [J]. Chin Med J （Engl），2021， 134（7）：783-791.
[3] Cao Y，Ni X，Wang Y，et al. Clinical and prognostic significa- nce of combined plasma fibrinogen concentrations and the monocyte-to-lymphocyte ratio in patients with ovarian cancer [J]. Ann Transl Med，2019，7（11）：242.
[4] Cheng F，Zeng C，Zeng L，et al. Clinicopathological and progn- ostic value of preoperative plasma fibrinogen in gastric cancer patients：A meta-analysis [J]. Medicine （Baltimore），2019， 98（40）：e17310.
[5] Dai T，Peng L，Lin G，et al. Preoperative elevated plasma fib- rinogen level predicts tumor recurrence and poor prognosis in patients with hepatocellular carcinoma [J]. J Gastrointest Oncol，2019，10（6）：1049-1063.
[6] Lin Y，Liu Z，Qiu Y，et al. Clinical significance of plasma D-dimer and fibrinogen in digestive cancer： A systematic review and meta-analysis [J]. Eur J Surg Oncol，2018，44（10）：1494-1503.
[7] Zhang Y，Cao J，Deng Y，et al. Pretreatment plasma fibrinogen level as a prognostic biomarker for patients with lung cancer [J]. Clinics （Sao Paulo），2020，75：e993.
[8] Izuegbuna OO，Agodirin OS，Olawumi HO，et al. Plasma D- Dimer and Fibrinogen Levels Correlates with Tumor Size and Disease Progression in Nigerian Breast Cancer Patients [J]. Cancer Invest，2021，39（8）：597-606.
[9] Li X，Shu K，Zhou J，et al. Preoperative Plasma Fibrinogen and D-dimer as Prognostic Biomarkers for Non-Muscle-Invasive Bladder Cancer [J]. Clin Genitourin Cancer，2020，18（1）：11-19.
[10] ■al?覦■kan S，Sungur M. Fibrinogen and D-dimer levels in pr- ostate cancer：Preliminary results [J]. Prostate Int，2017，5（3）：110-112.
[11] Hiraga T. Bone metastasis：Interaction between cancer cells and bone microenvironment [J]. J Oral Biosci，2019，61（2）： 95-98.
[12] Xie GS，Li G，Li Y，et al. Clinical association between pre- treatment levels of plasma fibrinogen and bone metastatic burden in newly diagnosed prostate cancer patients [J]. Chin Med J （Engl），2019，132（22）：2684-2689.
[13] 朱惠，陶吴东，黄彬，等.血浆纤维蛋白原与PCa骨转移的相关性及诊断价值研究[J].中华腔镜泌尿外科杂志（电子版），2021，15（2）：135-138.
[14] 冷区，苏维，李军，等.血浆纤维蛋白原水平与PCa临床病理特征的关系研究[J].中华腔镜泌尿外科杂志（电子版），2020，14（1）：12-15.
[15] Wang FM，Xing NZ. Systemic Coagulation Markers Especially Fibrinogen Are Closely Associated with the Aggressiveness of Prostate Cancer in Patients Who Underwent Tra- nsrectal Ultrasound-Guided Prostate Biopsy [J]. Dis Mar- kers，2021，2021：8899994.
[16] Cong X，Li S，Zhang Y，et al. The combination of preoperative fibrinogen and neutrophil-lymphocyte ratio is a predictive prognostic factor in esophagogastric junction and upper gastric cancer [J]. J Cancer，2019 ，10（22）：5518-5526.
[17] Wen J，Yang Y，Ye F，et al. The preoperative plasma fibrinogen level is an independent prognostic factor for overall survival of breast cancer patients who underwent surgical treatment [J]. Breast，2015，24（6）：745-750.
[18] Zheng S，Shen J，Jiao Y，et al. Platelets and fibrinogen facilitate each other in protecting tumor cells from natural killer cytotoxicity [J]. Cancer Sci，2009，100（5）：859-865.
[19] Tran C，Dicker A，Leiby B，et al. Utilizing digital health to collect electronic patient-reported outcomes in prostate cancer： single-arm pilot trial [J]. J Med Internet Res，2020， 22（3）： e12689.
[20] Roche Y，Pasquier D，Rambeaud JJ，et al. Fibrinogen mediates bladder cancer cell migration in an ICAM-1-dependent pathway [J]. Thromb Haemost，2003，89（6）：1089-1097.
[21] Tanaka N，Kikuchi E，Matsumoto K，et al. Prognostic value of plasma fibrinogen levels in patients with localized upper tract urothelial carcinoma [J]. BJU Int，2013，111（6）：857- 864.
[22] Li Y，Yang JN，Cheng SS，et al. Prognostic significance of FA score based on plasma fibrinogen and serum albumin in patients with epithelial ovarian cancer [J]. Cancer Manag Res， 2019，11：7697-7705.
[23] Deek MP，Tran PT. Oligometastatic and oligoprogression disease and local therapies in prostate cancer [J]. Cancer J，2020，26（2）：137-143.
[24] Song J，Yu T，Sun Z，et al. Comparison of prognostic significance between serum fibrinogen and global registry of acute coronary events score for prognosis of patients with non-st-elevation acute coronary syndromes undergoing percutaneous coronary intervention [J]. Coron Artery Dis，2020，31（2）：124-129.
[25] Bobek V. Anticoagulant and fibrinolytic drugs - possible agents in treatment of lung cancer? [J]. Anticancer Agents Med Chem，2012，12（6）：580-588.
[26] Park H，Lee SW，Song G，et al. Diagnostic Performance of %[-2]proPSA and Prostate Health Index for Prostate Cancer： Prospective，Multi-institutional Study [J]. J Korean Med Sci，2018，33（11）：e94.
[27] 汪鑫，蔡凯，王梁，等.PCa骨转移的预测因素分析[J].中国医科大学学报，2018，47（11）：1025-1028.
[28] 孙杨，王绍平.PSA、PSAD、F-PSA/PSA在PCa诊断中的价值分析[J].中国实验诊断学，2016，20（1）：113-114.
[29] Yiakoumos T，K?覿lble T，Rausch S. Prostate-specific antigen density as a parameter for the prediction of positive lymph nodes at radical prostatectomy [J]. Urol Ann，2015，7（4）：433-437.
[30] 胡新红，张涛.血清相关因子对PCa病理分期的预测价值[J].中国肿瘤临床与康复，2020，27（11）：1340-1343.
[31] 姚晓飞，董波，王宇刚，等.血清tPSA、PSAD、Gleason评分在PCa患者中的水平变化及预测价值[J].中国卫生工程学，2021，20（1）：122-123，126.
[32] Maruyama Y，Sadahira T，Araki M，et al. Factors predicting pathological upgrading after prostatectomy in patients with Gleason grade group 1 prostate cancer based on opinion-matched biopsy specimens [J]. Mol Clin Oncol，2020， 12（4）：384-389.