早产儿应用罗伊氏乳杆菌的临床观察

doi:10.20047/j.issn1673-7210.2023.17.21

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摘要目的观察早产儿应用罗伊氏乳杆菌DSM 17938的治疗效果。方法选择2019年1月至2022年7月北京和睦家医院出生且入住新生儿重症监护室的63例早产儿为研究对象，按照随机数字表法分为添加益生菌组和不添加益生菌组。不添加益生菌组采取普通治疗；添加益生菌组在普通治疗的基础上给予罗伊氏乳杆菌DSM 17938，持续服用至出院。同时根据胎龄分为≤28周（10例）、＞28周（53例），根据体重分为≤1 500 g（26例）、＞1 500 g（37例）。观察各组治疗效果。结果添加益生菌组呕吐消失时间、达到全胃肠内营养时间、恢复出生体重时间短于不添加益生菌组，满月体重增长多于不添加益生菌组（P＜0.05）。胎龄≤28周，添加益生菌组达到全胃肠内营养时间短于不添加益生菌组（P＜0.05）。胎龄＞28周，添加益生菌组呕吐消失时间、达到全胃肠内营养时间短于不添加益生菌组，满月体重增长多于不添加益生菌组（P＜0.05）。出生体重≤1 500 g，添加益生菌组达到全胃肠内营养时间短于不添加益生菌组，满月体重增长多于不添加益生菌组（P＜0.05）。出生体重＞1 500 g，添加益生菌组达到全胃肠内营养时间短于不添加益生菌组，满月体重增长多于不添加益生菌组（P＜0.05）。两组均未发生新生儿坏死性小肠结肠炎及院内感染。结论使用罗伊氏乳杆菌DSM 17938可缩短达到全胃肠内营养时间，满月体重增长更多，对早产儿治疗有明确效果。

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	李旭冉1　　邢蒙1　　张银柱2　　王瑞娟1　　侯新琳3　　杨明2▲

关键词 ：罗伊氏乳杆菌DSM 17938, 早产儿, 全胃肠内营养, 体重增长

Abstract：Objective To observe the therapeutic effects of Lactobacillus reuteri DSM 17938 on premature infants. Methods From January 2019 to July 2022, 63 cases of premature infants born and admitted to Neonatal Intensive Care Unit of Beijing United Family Hospital were selected as the study subjects. According to the random number table method, they were divided into with probiotics group and without probiotics group. The without probiotics group received general treatment; with probiotics group was given Lactobacillus reuteri DSM 17938 on the basis of general treatment, and continued to be administered until discharge. At the same time, according to gestational age, they were divided into≤28 weeks group (10 cases), ＞28 weeks group (53 cases), and according to weight, they were divided into≤1 500 g (26 cases) and ＞1 500 g (37 cases). The therapeutic effect of each group was observed. Results The time of vomiting disappearance, the time of reached total gastrointestinal nutrition, and the time to regain birth weight in with probiotics group were shorter than those in without probiotics group, and the weight gain at the full moon was more than that in without probiotics group (P＜0.05). Gestational age ≤28 weeks, the time of reached total gastrointestinal nutrition in with probiotics group was shorter than that in without probiotics group (P＜0.05). Gestational age ＞28 weeks, the time of vomiting disappearance and the time of reached total gastrointestinal nutrition in with probiotics group were shorter than those in without probiotics group, and the weight gain at the full moon was more than that in without probiotics group (P＜0.05). Birth weight ≤1 500 g, the time of reached total gastrointestinal nutrition in with probiotics group was shorter than that in without probiotics group, and the weight gain at the full moon was more than that in without probiotics group (P＜ 0.05). Birth weight ＞1 500 g, the time of reached total gastrointestinal nutrition in with probiotics group was shorter than that in without probiotics group, and the weight gain at the full moon was more than that in without probiotics group (P＜0.05). No necrotizing enterocolitis or nosocomial infection occurred in two groups. Conclusion The use of Lactobacillus reuteri DSM 17938 can shorten the time of reached total gastrointestinal nutrition and the weight gain at the full moon, which has a definite effect on the treatment of premature infants.

Key words： Lactobacillus reuteri DSM 17938 Premature infant Total gastrointestinal nutrition Weight gain

基金资助:首都卫生发展科研专项项目（首发2022-3- 40715）。

通讯作者: ▲通讯作者

引用本文:

李旭冉1　　邢蒙1　　张银柱2　　王瑞娟1　　侯新琳3　　杨明2▲. 早产儿应用罗伊氏乳杆菌的临床观察[J]. 中国医药导报, 2023, 20(17): 94-98.
LI Xuran1 XING Meng1 ZHANG Yinzhu2 WANG Ruijuan1 HOU Xinlin3 YANG Ming2▲. Clinical observation of Lactobacillus reuteri applied to premature infants. 中国医药导报, 2023, 20(17): 94-98.

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