中药抑制金黄色葡萄球菌的研究进展
杜春雨 王佳贺▲
中国医科大学附属盛京医院老年病科,辽宁沈阳 110004
Research progress of traditional Chinese medicine on anti-Staphylococcus aureus
DU Chunyu WANG Jiahe▲
Department of Geriatrics, Shengjing Hospital Affiliated to China Medical University, Liaoning Province, Shenyang 110004, China
摘要 金黄色葡萄球菌是最常见的医院和社区获得性致病菌之一,近年来其耐药菌株爆发流行趋势逐渐严重,有效治疗方案却极为有限,致使其感染的发病率、死亡率均很高。无数的实践均证明,中药的抗菌疗效不容置疑,尤其针对目前抗生素治疗无效的耐药菌株,中药有着广阔的应用前景。本文将综述有关中药治疗金黄色葡萄球菌的相关研究进展,为指导临床制订有效治疗方案提供新思路。
关键词 :
金黄色葡萄球菌 ,
中药 ,
耐药性 ,
抗菌活性
Abstract :Staphylococcus aureus (SA) is one of the most common pathogenic bacteria of hospital and community acquisition. In recent years, the trend of outbreak of drug-resistant strains of Staphylococcus aureus is gradually serious, but the effective treatment program is extremely limited, resulting in high morbidity and mortality of its infection. Numerous practices have proved that the antibacterial effect of traditional Chinese medicine is beyond doubt, especially for the resistant strains that are ineffective in antibiotic treatment, traditional Chinese medicine has a broad application prospect. This paper reviews the research progress of Chinese medicine in the treatment of Staphylococcus aureus and provides a new idea for guiding the clinical development of effective treatment.
Key words :
Staphylococcus aureus
Chinese traditional medicine
Drug resistance
Antimicrobial activity
通讯作者:
▲通讯作者
[1] Zhao G,Jiang K,Wu H,et al. Polydatin reduces Staphylococcus aureus lipoteichoic acid-induced injury by attenuating reactive oxygen species generation and TLR2-NFjB signaling [J]. J Cell Mol Med,2017,21(11):2796-2808.
[2] Cai JY,Li J,Hou YN,et al. Concentration-dependent dual effects of silibinin on kanamycin-induced cellsdeath in Staphylococcus aureus [J]. Biomed Pharmacother,2018,102:782-791.
[3] Zuo GY,Zhang XJ,Yang CX,et al. Evaluation of traditional Chinese medicinal plants for anti-MRSA activity with reference to the treatment record of infectious diseases [J]. Molecules,2012,17(3):2955-2967.
[4] Yin S,Rao G,Wang J,et al. Roemerine Improves the Survival Rate of Septicemic BALB/c Mice by Increasing the Cell Membrane Permeability of Staphylococcus aureus [J]. PLoS One,2015,10(11):e0143863.
[5] 游思湘,孟海波,符晨星,等.耐药金黄色葡萄球菌gyrA基因突变与中药耐药抑制剂的回复突变研究[J].中国兽医杂志,2013,49(9):3-5.
[6] Chen X,Shang F,Meng Y,et al. Ethanol extract of Sanguisorba officinalis L. inhibits biofilm formation of methicillin-resistant Staphylococcus aureus in an ica-dependent manner [J]. J Dairy Sci,2015,98(12):8486-8491.
[7] 韩飞,幸仁汇,陈琳琦,等.中药抗细菌耐药性研究进展[J].中国中药杂志,2016,41(5):813-817.
[8] Wu D,Lu R,Chen Y,et al. Study of cross-resistance mediated by antibiotics,chlorhexidine and Rhizoma coptidis in Staphylococcus aureus [J]. J Glob Antimicrob Resist,2016, 7:61-66.
[9] 许桂花.黄连素的临床应用价值[J].当代医学,2010,16(33):34.
[10] He W,Ma J,Chen Y,et al. Ephedrine hydrochloride protects mice from Staphylococcus aureus-induced peritonitis [J]. Am J Transl Res,2018,10(3):670-683.
[11] Guo JJ,Dai BL,Chen NP,et al. The anti-Staphylococcus aureus activity of the phenanthrene fraction from fibrous roots of Bletilla striata [J]. BMC Complemnt Altern Met,2016,16(1):491.
[12] Jiang X,Wang Y,Qin Y,et al. Micheliolide provides protection of mice against Staphylococcus aureus and MRSA infection by down-regulating inflammatory response [J]. Sci Rep,2017,7:41964.
[13] 曾春晖,杨柯,徐明光,等.广西藤茶总黄酮对金黄色葡萄球菌抗菌机制研究[J].中国实验方剂学杂志,2013, 19(10):249-252.
[14] 李乃谦.3种中药对金黄色葡萄球菌体外抑菌作用的比较[J].中国中医药咨讯,2011,3(7):198.
[15] Jiang KF,Zhao G,Deng GZ,et al. Polydatin ameliorates Staphylococcus aureus-induced mastitis in mice via inhibiting TLR2-mediated activation of the p38 MAPK/NF-κB pathway [J]. Acta pharmacol Sin,2017,38(2):211-222.
[16] 章德林,汤丹丰,郑琴,等.具有抗感染作用的中药分类研究[J].中草药,2015,46(24):3771-3778.
[17] 宓伟,何深一.抗耐甲氧西林金黄色葡萄球菌的中药筛选[J].中国生化药物杂志,2011,32(1):44-46.
[18] 佟天天,黄浩,王义明,等.60味中药提取物抗菌活性的研究[J].世界科学技术-中医药现代化,2012,15(6):1268-1273.
[19] 冯韬,何玉张,李志强,等.6味中药提取物对金黄色葡萄球菌生物膜形成的抑制作用[J].中国兽医杂志,2017, 53(1):16-19.
[20] 刘秀玮,李静.中药麻鱼石黄汤对金黄色葡萄球菌体外抑菌作用的实验研究[J].中国中医急症,2013,22(1):65-66.
[21] 陈海燕.万古霉素治疗耐甲氧西林金黄色葡萄球菌的疗效和血药浓度分析[J].中国现代医生,2016,54(24):110-112,116.
[22] 杨露,谢小芳,胡荣.麻黄附子细辛汤联合抗生素的体外抗耐甲氧西林金葡菌作用研究[J].成都中医药大学学报,2015,38(1):25-29.
[23] Yang ZC,Wang BC,Yang XS,et al. The synergistic activity of antibiotics combined with eight traditional Chinese medicines against two different strains of Staphylococcus aureus [J]. Colloids Surf B Biointerfaces,2005,41(2/3):79-81.
[24] 谢小燕.肺炎合剂联合利奈唑胺治疗耐甲阳西林金黄色葡萄球菌肺炎的临床疗效及其对血清炎性因子水平的影响[J].实用心脑肺血管病杂志,2017,25(7):96-99.
[25] 区林华,崔庆林,陈兰.2013~2015年我院临床常见病原菌耐药性分析[J].中国当代医药,2017,24(15):82-86.
[26] 高咏涵,谢鲲鹏,谢明杰.环丙沙星联合不同中药对金黄色葡萄球菌突变选择窗的影响[J].中国生化药物杂志,2016,36(5):192-194.
[27] Liu QQ,Han J,Zuo GY,et al. Potentiation activity of multiple antibacterial agents by Salvianolate from the Chinese medicine Danshen against methicillin-resistant Staphylococcus aureus(MRSA)[J]. J Pharmacol Sci,2016, 131(1):13-17.
[28] 吴梅梅,常明向.甲氧苄啶与58种中药联用抗菌增效作用的研究[J].中国医药导报,2015,12(13):27-35.
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