Efficacy of Shenqi Shiyiwei Granules combined with Levothyroxine Sodium Tablets in the treatment of Hashimoto thyroiditis with syndrome of yang deficiency of spleen and kidney
JIA Wei1 WANG Fen1 WANG Can1 LU Yating2 GUO Wenlu1 LI Xiaodie1 ZHU Defa1
1.Department of Geriatric Endocrinology, the First Affiliated Hospital of Anhui Medical University, Anhui Province, Hefei 230022, China;
2.Department of Endocrinology and Metabolic Diseases, the First Affiliated Hospital of Anhui Medical University, Anhui Province, Hefei 230022, China
Abstract：Objective To explore the efficacy of Shenqi Shiyiwei Granules combined with Levothyroxine Sodium Tablets in the treatment of Hashimoto thyroiditis (HT) with syndrome of yang deficiency of spleen and kidney. Methods A total of 90 HT patients with syndrome of yang deficiency of spleen and kidney admitted to the First Affiliated Hospital of Anhui Medical University from April 2020 to October 2021 were selected. Patients were divided into control 1, 2 groups, and treatment group according to random number table method, with 30 cases in each group. Control 1 group was given Levothyroxine Sodium Tablets, control 2 group was given Shenqi Shiyiwei Granules, treatment group was given Levothyroxine Sodium Tablets combined with Shenqi Shiyiwei Granules. The treatment course of the three groups was three months. The clinical efficacy and traditional Chinese medicine symptom scores, thyroid hormone indexes, thyroid antibody indexes, inflammatory factors, and lymphocyte subsets before and after treatment were compared among the three groups. Results The clinical efficacy of the treatment group was better than that of control 1 and 2 groups (P＜0.05). After treatment, traditional Chinese medicine symptom scores, anti-thyroglobulin antibody, anti-thyroid peroxidase antibody, thyrotropin hormone, and interleukin-6 levels in the three groups were lower than those before treatment, and those in treatment group were lower than those in control 1 and 2 groups (P＜0.05). After treatment, the CD4+/CD8+ levels in three groups were higher than those before treatment (P＜0.05). After treatment, the free triiodothyronine, free thyroid hormone, CD3+, CD4+, CD8+, and interleukin-10 levels in three groups were higher than those before treatment, and those in treatment group were higher than those in control 1 and 2 groups (P＜0.05). Conclusion Shenqi Shiyiwei Granules combined with Levothyroxine Sodium Tablets have significant effects in the treatment of HT with syndrome of yang deficiency of spleen and kidney, which can improve symptoms, reduce inflammatory factors, and maintain the stability of immune cells.
贾伟1 王芬1 王灿1 陆雅婷2 郭文露1 李晓蝶1 朱德发1. 参芪十一味颗粒联合左甲状腺素钠片治疗脾肾阳虚型桥本甲状腺炎的效果[J]. 中国医药导报, 2023, 20(15): 77-81.
JIA Wei1 WANG Fen1 WANG Can1 LU Yating2 GUO Wenlu1 LI Xiaodie1 ZHU Defa1. Efficacy of Shenqi Shiyiwei Granules combined with Levothyroxine Sodium Tablets in the treatment of Hashimoto thyroiditis with syndrome of yang deficiency of spleen and kidney. 中国医药导报, 2023, 20(15): 77-81.
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