Research progress on the molecular mechanism of somatostatin in the treatment of obesity
SUN Shuoshuo1 WEI Xiao1 ZHANG Shaohong2 LIU Chao1
1.Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210028, China;
2.Department of Geriatrics, the Affiliated Huaian NO.1 People’s Hospital of Nanjing Medical University, Jiangsu Province, Huaian 223300, China
Abstract：The prevalence of obesity is increasing year by year, and obesity is a potential risk factor for many chronic diseases. However, obesity treatment faces problems such as few drug options and many side effects. Somatostatin (SST) plays an important role in food intake and appetite regulation. More and more evidence suggests that SST has potential value of clinical application in the management of obesity by affecting satiety and feeding behavior. SST can effectively regulate the occurrence and development of obesity and its related diseases by forming a wide regulatory network with insulin, agouti-related peptide, proopiomelanocortin, leptin, ghrelin, and brain-derived neurotrophic factor. The in-depth study of the role and mechanism of SST in weight loss will open up a new perspective for the development of new drugs for the treatment of obesity. In addition, considering the limitations of natural hormones, SST analogs are good candidates for the treatment of obesity and are expected to be widely developed for clinical application. According to the existing problems, this paper also proposes specific research directions in the future, aiming at providing relevant scientific basis for the treatment of obesity.
孙烁烁1 韦晓1 张少红2 刘超1. 生长抑素治疗肥胖的分子机制研究进展[J]. 中国医药导报, 2023, 20(15): 53-56.
SUN Shuoshuo1 WEI Xiao1 ZHANG Shaohong2 LIU Chao1. Research progress on the molecular mechanism of somatostatin in the treatment of obesity. 中国医药导报, 2023, 20(15): 53-56.
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