周细胞-内皮细胞Crosstalk在心肌缺血后微血管新生中的研究进展

doi:10.20047/j.issn1673-7210.2023.15.07

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摘要心血管疾病是世界公共卫生问题，是人类主要的死亡原因之一。治疗性血管新生能够有效减轻心肌缺血损伤并改善心功能，已成为心肌缺血后重要的补充治疗策略。周细胞-内皮细胞Crosstalk对心肌缺血后微血管新生的调控机制主要包括周细胞通过血管基底膜直接接触内皮细胞和旁分泌调节两种模式。其中，旁分泌调节主要通过促血管新生细胞因子和激活多种信号通路，以促进微血管新生和成熟，对稳定血管/血液系统及改善心脏功能等具有重要作用，因此，周细胞-内皮细胞Crosstalk是心肌缺血后微血管新生的关键环节。本文综述了周细胞-内皮细胞Crosstalk在心肌缺血后微血管新生中的机制及作用，以期为心肌缺血的补充治疗方案提供思路。

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	刘艺旋1　　汤凯璇2　　李奕潼1　　周煊程2　　刘怡然1　　李超3

关键词 ：周细胞-内皮细胞Crosstalk, 微血管新生, 旁分泌调节, 作用机制

Abstract：Cardiovascular disease is a world public health problem and one of the main causes of human death. Therapeutic angiogenesis can effectively alleviate myocardial ischemia injury and improve cardiac function, which has become an important supplementary treatment strategy after myocardial ischemia. The regulation mechanism of pericyte-endothelial cell Crosstalk on micro angiogenesis after myocardial ischemia mainly includes pericyte contact with endothelial cells through vascular basement membrane and paracrine regulation. Paracrine regulation plays an important role in stabilizing blood vessel/blood system, and improving cardiac function by promoting angiogenesis cytokines, and activating various signal pathways to promote angiogenesis and maturation. Therefore, pericyte-endothelial cell Crosstalk is the key link of micro angiogenesis after myocardial ischemia. This paper reviews the mechanism and role of pericyte-endothelial cell Crosstalk in micro angiogenesis after myocardial ischemia in order to provide ideas for complementary treatment of myocardial ischemia.

Key words： Pericyte-endothelial cell Crosstalk Micro angiogenesis Paracrine regulation Mechanism of action

基金资助:国家自然科学基金资助项目（82004276）；
省级大学生创新训练计划项目（S202210441019）。

通讯作者: 李超（1990.9-），男，博士，博士后，副教授，硕士生导师；研究方向：心血管病理和药理研究。

引用本文:

刘艺旋1　　汤凯璇2　　李奕潼1　　周煊程2　　刘怡然1　　李超3. 周细胞-内皮细胞Crosstalk在心肌缺血后微血管新生中的研究进展[J]. 中国医药导报, 2023, 20(15): 40-44.
LIU Yixuan1 TANG Kaixuan2 LI Yitong1 ZHOU Xuancheng2 LIU Yiran1 LI Chao3. Research progress on pericyte-endothelial cell Crosstalk in micro angiogenesis after myocardial ischemia. 中国医药导报, 2023, 20(15): 40-44.

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[1] Zhai S，Zhang XF，Lu F，et al. Chinese medicine GeGen-DanShen extract protects from myocardial ischemic injury through promoting angiogenesis via up-regulation of VEGF/ VEGFR2 signaling pathway [J]. J Ethnopharmacol，2021，267： 113475.
[2] Quijada P，Trembley MA，Small EM. The Role of the Epicardium During Heart Development and Repair [J]. Circ Res，2020，126（3）：377-394.
[3] Payne LB，Zhao H，James CC，et al. The pericyte microenvironment during vascular development [J]. Microcirculation，2019，26（8）：e12554.
[4] Cossutta M，Darche M，Carpentier G，et al. Weibel-Palade Bodies Orchestrate Pericytes During Angiogenesis [J]. Arterioscler Thromb Vasc Biol，2019，39（9）：1843-1858.
[5] Zonneville J，Safina A，Truskinovsky AM，et al. TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association [J]. BMC Cancer，2018，18（1）： 1-13.
[6] Li Y，Sun R，Zou J，et al. Dual Roles of the AMP-Activated Protein Kinase Pathway in Angiogenesis [J]. Cells，2019，8（7）：1-16.
[7] Carbone C，Piro G，Merz V，et al. Angiopoietin-like proteins in angiogenesis，inflammation and cancer [J]. Int J Mol Sci，2018，19（2）：1-22.
[8] Polacheck WJ，Kutys ML，Yang J，et al. A non-canonical Notch complex regulates adherens junctions and vascular barrier function [J]. Nature，2017，552（7684）：258-262.
[9] Bai J，Khajavi M，Sui L，et al. Angiogenic responses in a 3D micro-engineered environment of primary endothelial cells and pericytes [J]. Angiogenesis，2021，24（1）：111-127.
[10] Braile M，Marcella S，Cristinziano L，et al. VEGF-A in car- diomyocytes and heart diseases [J]. Int J Mol Sci，2020， 21（15）：1-18.
[11] Tanaka K，Watanabe M，Tanigaki S，et al. Tumor necrosis factor-α regulates angiogenesis of BeWo cells via synergy of PlGF/VEGFR1 and VEGF-A/VEGFR2 axes [J]. Place- nta，2018，74：20-27.
[12] Eilken HM，Diéguez-Hurtado R，Schmidt I，et al. Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1 [J]. Nat Commun，2017，8（1）：1-14.
[13] Caporale A，Martin AD，Capasso D，et al. Short PlGF-derived peptides bind VEGFR-1 and VEGFR-2 in vitro and on the surface of endothelial cells [J]. J Pept Sci，2019， 25（5）：e3146.
[14] Kalra K，Eberhard J，Farbehi N，et al. Role of PDGF-A/B Ligands in Cardiac Repair After Myocardial Infarction [J]. Front Cell Dev Biol，2021，9：669188.
[15] Mamer SB，Chen S，Weddell JC，et al. Author correction：discovery of high-affinity PDGF-VEGFR interactions：redefining RTK dynamics [J]. Sci Rep，2020，10（1）：1-2.
[16] Farbehi N，Patrick R，Dorison A，et al. Single-cell expression profiling reveals dynamic flux of cardiac stromal，vascular and immune cells in health and injury [J]. Elife，2019， 8：e43882.
[17] Kisler K，Nelson AR，Rege SV，et al. Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain [J]. Nat Neurosci，2017，20（3）：406-416.
[18] Luo W，Gong Y，Qiu F，et al. NGF nanoparticles enhance the potency of transplanted human umbilical cord mesenchymal stem cells for myocardial repair [J]. Am J Physiol Heart Circ Physiol，2021，320（5）：H1959-H1974.
[19] Jia T，Jacquet T，Dalonneau F，et al. FGF-2 promotes angiogenesis through a SRSF1/SRSF3/SRPK1-dependent axis that controls VEGFR1 splicing in endothelial cells [J]. BMC Biol，2021，19（1）：1-26.
[20] Xie Y，Su N，Yang J，et al. FGF/FGFR signaling in health and disease [J]. Signal Transduct Target Ther，2020，5（1）：1-38.
[21] Hossain MA，Adithan A，Alam MJ，et al. IGF-1 Facilitates Cartilage Reconstruction by Regulating PI3K/AKT，MAPK，and NF-kB Signaling in Rabbit Osteoarthritis [J]. J Inflamm Res，2021，14：3555-3568.
[22] Yan L，He X，Tang Y，et al. HGF can reduce accumulation of inflammation and regulate glucose homeostasis in T2D mice [J]. J Physiol Biochem，2021，77（4）：613-624.
[23] Xiang Y，Yao X，Wang X，et al. Houshiheisan promotes angiogenesis via HIF-1α/VEGF and SDF-1/CXCR4 path- ways：in vivo and in vitro [J]. Biosci Rep，2019，39（10）： BSR 20191006.
[24] Rathjen T，Kunkemoeller B，Cederquist CT，et al. Endothelial Cell Insulin Signaling Regulates CXCR4 （C-X-C Motif Chemokine Receptor 4） and Limits Leukocyte Adhesion to Endothelium [J]. Arterioscler Thromb Vasc Biol，2022，42（7）： e217-e227.
[25] Dimova I，Karthik S，Makanya A，et al. SDF-1/CXCR4 signalling is involved in blood vessel growth and remodelling by intussusception [J]. J Cell Mol Med，2019，23（6）：3916- 3926.
[26] Huang X，Mao W，Zhang T，et al. Baicalin promotes apoptosis and inhibits proliferation and migration of hypoxia-induced pulmonary artery smooth muscle cells by up-regulating A2a receptor via the SDF-1/CXCR4 signaling pathway [J]. BMC Complement Altern Med，2018，18（1）：1-13.
[27] Li ZH，Wang YL，Wang HJ，et al. Rapamycin-Preactivated Autophagy Enhances Survival and Differentiation of Mesenchymal Stem Cells After Transplantation into Infarcted Myocardium [J]. Stem Cell Rev Rep，2020，16（2）：344- 356.
[28] Su H，Cantrell AC，Zeng H，et al. Emerging role of pericytes and their secretome in the heart [J]. Cells，2021，10（3）： 548.
[29] An D，Chung-Wah-Cheong J，Yu D Y，et al. Alpha-Smooth Muscle Actin Expression and Parafoveal Blood Flow Pathways Are Altered in Preclinical Diabetic Retinopathy [J]. Invest Ophthalmol Vis Sci，2022，63（5）：1-16.
[30] Aslam M，Gündüz D，Troidl C，et al. Purinergic regulation of endothelial barrier function [J]. Int J Mol Sci，2021，22（3）：1207.
[31] Zhou Q，Tu T，Tai S，et al. Endothelial specific deletion of HMGB1 increases blood pressure and retards ischemia recovery through eNOS and ROS pathway in mice [J]. Redox Biol，2021，41：101890.
[32] Ashraf JV，Al Haj Zen A. Role of Vascular Smooth Muscle Cell Phenotype Switching in Arteriogenesis [J]. Int J Mol Sci，2021，22（19）：10585.
[33] Tsuchiya T，Doi R，Obata T，et al. Lung microvascular niche，repair，and engineering [J]. Front Bioeng Biotechnol，2020， 8：1-19.
[34] Avolio E，Katare R，Thomas AC，et al. Cardiac pericyte reprogramming by MEK inhibition promotes arteriologenesis and angiogenesis of the ischemic heart [J]. J Clin Invest， 2022，132（10）：e152308.
[35] Costa MA，Paiva AE，Andreotti JP，et al. Pericytes constrict blood vessels after myocardial ischemia [J]. J Mol Cell Cardiol，2018，116：1-4.