Re-evaluation of systematic reviews and meta analyses of Pembrolizumab treatment of advanced non-small cell lung cancer
WANG Bing1 WAN Ning1,2 XIE Fei2 YANG Ning3 XU Xiaoling1 LIANG Hongyi2 JI Bo2 YUAN Jin1#br#
1.School of Pharmaceutical Sciences, Southern Medical University, Guangdong Province, Guangzhou 510515, China;
2.Department of Clinical Pharmacy, Guangdong Branch Center, National Clinical Research Center for Geriatric Diseases (Chinese People’s Liberation Armg General Hospital) General Hospital of Southern Theater Command, Guangdong Province, Guangzhou 510010, China;
3.Department of Oncology, General Hospital of Southern Theater Command, Guangdong Province, Guangzhou 510010, China
Abstract：Objective To re-evaluate the quality of published systematic reviews of Pembrolizumab for advanced non-small cell lung cancer. Methods Systematic reviews of Pembrolizumab for advanced non-small cell lung cancer were collected from PubMed, EMBase, Cochrane Library, Web of Science, CNKI, VIP, and Wanfang databases from to February 2022. PRISMA statement, AMSTAR 2 and GRADE tools were used to evaluate the reporting quality, methodological quality, and evidence quality of the included systematic reviews. Results A total of ten systematic reviews were included. The PRISMA score ranged from 20-26. The evaluation results of AMSTAR 2 tool indicated that eight items were reported completely, two items were not reported. The grading results of GRADE showed that the outcome indexes of systematic reviews were mainly of low quality. Conclusion Current evidence shows that Pembrolizumab has significant clinical benefits in the treatment of advanced non-small cell lung cancer. However， the methodological quality of systematic reviews is insufficient， and the evidence quality of evidence-based medicine needs to be further improved.
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