血清白细胞免疫球蛋白样受体亚家族B2水平在结直肠癌患者中的诊断价值

doi:10.20047/j.issn1673-7210.2023.14.22

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摘要目的探讨白细胞免疫球蛋白样受体亚家族B2（LILRB2）水平在结直肠癌（CRC）患者中的诊断价值。方法选取2021年1月至2022年5月于潍坊医学院附属医院（以下简称“我院”）确诊的CRC患者125例为CRC组，筛选同期于我院进行健康检查人群120名为对照组。采用酶联免疫吸附试验法及电化学发光法分别检测CRC组和对照组血清LILRB2、癌胚抗原（CEA）、糖类抗原199（CA199）水平。对所得数据进行统计学处理，分析LILRB2在CRC患者中的诊断价值。结果 CRC组血清LILRB2、CA199、CEA水平均高于对照组，差异有统计学意义（P＜0.05）。不同年龄、淋巴结转移、脉管癌栓、浸润深度、TNM分期患者血清LILRB2水平比较，差异有统计学意义（P＜0.05）。受试操作特征曲线结果显示，血清LILRB2、CA199、CEA及三者联合检测的曲线下面积分别为0.7593、0.5727、0.7234、0.7889；三者联合检测的诊断效能高于CA199、CEA单独检测,差异有统计学意义（P＜0.05）；而其与LILRB2比较，差异无统计学意义（P＞0.05）。TNM Ⅰ+Ⅱ期患者的LILRB2诊断敏感度高于TNM Ⅲ+Ⅳ期，差异有统计学意义（P＜0.05）。结论 CRC患者血清LILRB2水平对CRC诊断具有一定的临床价值。

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	耿琰1　　黄琰2　　王子传1　　刘天姿1　　彭鑫童1　　刘静2

关键词 ：白细胞免疫球蛋白样受体亚家族B2, 结直肠癌, 临床病理特征, 早期诊断

Abstract：Objective To investigate the diagnosis value of leukocyte immunoglobulin-like receptor subfamily B2 (LILRB2) levels in patients with colorectal cancer (CRC). Methods A total of 125 CRC patients diagnosed in Affiliated Hospital of Weifang Medical University （“our hospital” for short） from January 2021 to May 2022 were selected as CRC group, and 120 patients who underwent physical examination in our hospital during the same period were selected as control group. The serum LILRB2, carcinoembryonic antigen (CEA), and carbohydrate antigen 199 (CA199) levels of the CRC group and control group were detected using enzyme-linked immunosorbent assay and electrochemiluminescence method, respectively. Data were statistically processed to analyze the diagnostic value of LILRB2 in patients with CRC. Results Serum LILRB2, CA199, and CEA expressions in the CRC group were higher than those in the control group, the differences were statistically significant (P＜0.05). Statistically significant differences were observed in serum LILRB2 levels among patients of different ages, lymph node metastasis, vascular tumor thrombus, depths of invasions, and TNM stages (P＜0.05). Receiver operating characteristic curve results showed, the area under curve for serum LILRB2, CA199, CEA, and combined detection of the three were 0.7593, 0.5727, 0.7234, and 0.7889, respectively. The diagnostic efficiency of the combined detection of the three was higher than that of CA199 and CEA alone, the differences were statistically significant(P＜0.05). There were no significant differences between the combined detection of the three and LILRB2 (P＞0.05). The diagnostic sensitivity of LILRB2 in TNM Ⅰ+Ⅱ patients was higher than that in TNM Ⅲ+Ⅳ patients, the differences were statistically significant (P＜0.05). Conclusion Serum LILRB2 level in CRC patients has certain clinical value in diagnosis of CRC.

Key words： Leukocyte immunoglobulin-like receptor subfamily B2 Colorectal cancer Clinicopathological features Early diagnosis

基金资助:山东省医药卫生科技发展计划项目（202103030672）。

通讯作者: 刘静（1987.8-），女，硕士；研究方向：肿瘤疾病的临床研究。

作者简介: 耿琰（1993.12-），女，潍坊医学院2020级肿瘤学专业在读硕士研究生；研究方向：肿瘤相关疾病。

引用本文:

耿琰1　　黄琰2　　王子传1　　刘天姿1　　彭鑫童1　　刘静2. 血清白细胞免疫球蛋白样受体亚家族B2水平在结直肠癌患者中的诊断价值[J]. 中国医药导报, 2023, 20(14): 102-105,127.
GENG Yan1 HUANG Yan2 WANG Zichuan1 LIU Tianzi1 PENG Xintong1 LIU Jing2. Diagnosis value of serum leukocyte immunoglobulin-like receptor subfamily B2 level in the diagnosis of colorectal cancer. 中国医药导报, 2023, 20(14): 102-105,127.

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