Effects of low molecular weight heparin combined with Adenosine Triphosphate and Coenzyme A on fetal growth restriction
GU Laimei1 ZHAO Shuxia1 HUANG Yan2
1.Department of Obstetrics and Gynecology, Beijing Huairou Hospital, Beijing 101400, China;
2.Department of Obstetrics and Gynecology, Nantong Maternal and Child Health Hospital, Jiangsu Province, Nantong 226000, China
Abstract：Objective To observe the effects of low molecular weight heparin combined with Adenosine Triphosphate and Coenzyme A on fetal growth restriction. Methods A total of 240 pregnant women with fetal growth restriction admitted to Beijing Huairou Hospital from January 2017 to December 2020 were selected as study object, and they were divided into control group (120 cases, receiving Adenosine Triphosphate combined with Coenzyme A) and study group (120 cases, receiving low molecular weight heparin on the basis of control group) by random number table method. The treatment time of both groups was one week. Fetal growth and development, clinical efficacy, gestational age, neonatal umbilical cord blood gas, and maternal and infant outcomes were compared between two groups; amniotic fluid indexes before and after treatment were compared between two groups. Results Fetal head circumference, abdominal circumference, double parietal diameter, and uterine height in the study group were higher than those in the control group (P＜0.05). The clinical effect of the study group was better than that of the control group (P＜0.05). After treatment, the amniotic fluid indexes in both groups were higher than those before treatment, and those in the study group were higher than those in the control group (P＜0.05). The gestational week and oxygen partial pressure of study group were higher than those of control group, while the carbon dioxide fraction was lower than that of control group (P＜0.05); there was no significant difference in delivery mode between the two groups (P＞0.05). The total incidence of pregnancy complications in study group was lower than that in control group (P＜0.05). The incidence of preterm infants and full-term infants in study group was lower than that in control group, and Apgar score was higher than that in control group (P＜0.05); there were no significant differences in neonatal asphyxia rate and perinatal mortality between two groups (P＞0.05). Conclusion Low molecular weight heparin combined with Adenosine Triphosphate and Coenzyme A is effective in the treatment of fetal growth restriction, can promote fetal growth and development, and can improve maternal and infant outcomes.
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