自噬与念珠菌致病及耐药的相关性

doi:10.20047/j.issn1673-7210.2023.14.09

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摘要自噬是真核细胞固有的降解代谢途径，参与细胞器降解、营养平衡、程序性死亡等生物学过程，以调控真菌感染发生关键环节所需的形态转变和细胞分化。适度的自噬能够保护真菌抵御不良生存环境，而自噬失衡则可致细胞自噬性死亡。念珠菌是引发住院患者发生侵袭性真菌感染的首要病原菌。自噬在调控念珠菌致病性和耐药性方面扮演重要角色。因此，本文旨在对自噬发生的分子机制及自噬在念珠菌中的研究现状进行综述，以期为念珠菌的防治及抗真菌药物研发提供新的思路。

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	李贞　　陈伟琴

关键词 ：念珠菌, 耐药性, 自噬, 选择性自噬

Abstract：Autophagy is an inherent degradation metabolic pathway of eukaryotic cells. It is involved in biological processes such as organelle degradation, nutrient balance, and programmed death to regulate the morphological transformation and cell differentiation required for the key links of fungal infection. Moderate autophagy protects fungi against a poor living environment, and an imbalance of autophagy leads to autophagic cell death. Candida is the leading pathogen causing invasive fungal infections in hospitalized patients. Autophagy plays an important role in regulating the pathogenicity and drug resistance of Candida. Therefore, this paper aims to review the molecular mechanism of autophagy and the research status of autophagy in Candida, in order to provide new ideas for the prevention-treatment strategies of Candida and the research and development of antifungal drugs.

Key words： Candida Drug resistance Autophagy Selective autophagy

基金资助:国家自然科学基金资助项目（82003817）。

通讯作者: 陈伟琴（1985.6-），女，硕士；研究方向：中西医结合防治感染。

作者简介: 李贞（1988.1-），女，硕士；研究方向：真菌耐药及致病机制。

引用本文:

李贞　　陈伟琴. 自噬与念珠菌致病及耐药的相关性[J]. 中国医药导报, 2023, 20(14): 43-46,51.
LI Zhen　CHEN Weiqin. Correlation between autophagy and Candida pathogenicity and drug resistance. 中国医药导报, 2023, 20(14): 43-46,51.

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