Clinical effect observation of Cangfu Daotan Decoction on the treatment of simple obesity with dyslipidemia of phlegm dampness type complicated with dyslipidemia
YANG Xinyu1 YANG Hua1 TANG Hong1 FENG Shengyu2 MA Yanyun1 ZOU Ran3 PAN Keyi1 JI Benwei1
1.Department of Endocrinology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;
2.Internal Medicine of Chinese Medicine, Shanghai Songjiang District Fangta Hospital of Traditional Chinese Medicine, Shanghai 201600, China;
3.Department of Endocrinology, Shanghai Changning District Tianshan Hospital of Traditional Chinese Medicine, Shanghai 200051, China
Abstract：Objective To survey the clinical effect of Cangfu Daotan Decoction on the treatment of simple obesity with dyslipidemia of phlegm dampness type complicated with dyslipidemia. Methods A total of 72 cases of simple obesity with dyslipidemia of phlegm dampness type were selected from the outpatients or inpatients of Department of Endocrinology of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from September 2018 to January 2020. They were divided into control group and treatment group according to random number table method, with 36 cases in each group. The control group were treated with basic treatment and Metformin, the treatment group were treated with Cangfu Daotan Decoction based on the control group. Both groups were treated for 12 weeks. Body mass index (BMI), abdominal circumference, insulin resistance index (HOMA-IR), blood lipid, traditional Chinese medicine syndrome score and clinical efficacy of the two groups before and after treatment were observed. After treatment, BMI, abdominal circumference, HOMA-IR, blood lipid and traditional Chinese medicine syndrome score in both groups were lower than those before treatment, and the treatment group was lower than the control group (P＜0.05). After treatment, total cholesterol, triglycerides, and low density lipoprotein cholesterol in both groups were decreased than those before treatment (P＜0.05), but there was no significant difference between the two groups (P＞0.05). The clinical effect of the treatment group was better than that of the control group (P＜0.05). Conclusion Cangfu Daotan Decoction can reduce the abdominal and waist circumference of simple obesity with dyslipidemia of phlegm dampness type, effectively improve the lipid metabolism and insulin resistance, and improve the clinical symptoms of the patients.
杨昕宇1 杨华1 唐红1 冯圣钰2 马燕云1 邹冉3 潘可怡1 吉本唯1. 加味苍附导痰汤治疗痰湿型单纯性肥胖症伴血脂异常的临床效果[J]. 中国医药导报, 2023, 20(12): 151-155.
YANG Xinyu1 YANG Hua1 TANG Hong1 FENG Shengyu2 MA Yanyun1 ZOU Ran3 PAN Keyi1 JI Benwei1. Clinical effect observation of Cangfu Daotan Decoction on the treatment of simple obesity with dyslipidemia of phlegm dampness type complicated with dyslipidemia. 中国医药导报, 2023, 20(12): 151-155.
[1] Ng M，Fleming T，Robinson M，et al. Global，regional，and national prevalence of overweight and obesity in children and adults during 1980—2013： a systematic analysis for the Global Burden of Disease Study 2013 [J]. Lancet，2014，384（9945）：766-781.
[2] 肥胖症中医诊疗方案专家共识[J].北京中医药大学学报，2022，45（8）：786-794.
[3] 国务院新闻办公室.《中国居民营养与慢性病状况报告 （2020年）》：我国超过一半成年居民超重或肥胖[J].中华医学信息导报，2020，35（24）：15.
[4] 中华医学会妇产科学分会内分泌学组及指南专家组.多囊卵巢综合征中国诊疗指南[J].中华妇产科杂志，2018， 53（1）：2-6.
[5] 中国超重/肥胖医学营养治疗专家共识（2016年版）[J].中华糖尿病杂志，2016，8（9）：525-535.
[6] 中国成人血脂异常防治指南（2016年修订版）[J].中国循环杂志，2016，31（10）：937-953.
[7] 陈湘君.中医内科学[M].上海：上海科学技术出版社，2013：120-123.
[8] 郑筱萸.中药新药临床研究指导原则[M].北京：中国医药科技出版社，2002.
[9] 安冬青，吴宗贵，梁春等.血脂异常中西医结合诊疗专家共识[J].中国全科医学，2017，20（3）：262-269.
[10] 王吉耀.内科学[M].北京：人民卫生出版社，2002：1007-1011.
[11] 母义明，纪立农，宁光，等.二甲双胍临床应用专家共识（2016年版）[J].中国糖尿病杂志，2016，24（10）：871-884.
[12] 史兴洲，郑曙琴.中成药治疗肥胖症用药规律研究[J].江西中医药，2014， 45（5）：12-13.
[13] 侯瑞芳，陶枫，陆灏，等.肥胖的中医治疗进展[J].中华中医药学刊，2015，33（8）：1959-1962.
[14] 马杭琨，徐凤芹.中药降脂机制及其有效降脂成分的研究进展[J].中西医结合心脑血管病杂志，2016，14（13）：1494-1496.
[15] 刘国生，孙备，明亮.苍术挥发油与水溶性成分的主要药理作用比较[J].安徽医科大学学报，2003，38（2）：124-126.
[16] 叶青，刘东升，王兰霞，等.茯苓化学成分、药理作用及质量控制研究进展[J].中医药信息：2023，40（2）：5.
[17] 姚俊宏，蒋秋冬，陈军，等.21种辛味中药挥发油透皮促渗效果的药性规律分析[J].中国实验方剂学杂志，2018， 24（1）：1-7.
[18] Kim BJ，Kim YK，Park WH，et al. A water-extract of the Korean traditional formulation Geiji-Bokryung-Hwan reduces atherosclerosis and hypercholesteremia in cholesterol- fed rabbits [J]. Int Immunopharmacol，2003，3（5）：723-734.
[19] 杨永清，杨明庆.肥胖诱发胰岛素抵抗的炎性机制[J].中国生物化学与分子生物学报，2012，28（8）：693.
[20] 孙升云，黄进，孟民杰，等.山荷减肥颗粒对饮食诱导肥胖大鼠瘦素、脂联素、抵抗素的影响[J].中国病理生理杂志，2009，25（6）：1170-1174.
[21] 吴亚柳，常晓彤.炎症-内质网应激-肠道菌群在胰岛素抵抗发病中的作用[J].生理科学进展，2017，48（3）：221-226.
[22] 宋桉，赵家俊.肥胖致胰岛素抵抗的机制研究新进展[J].中国老年学杂志，2013，33（17）：4359-4361.
[23] 房昉，赵杰，温伟波.辛味中药与胰岛素抵抗[J].中国医药导报，2016，13（34）：98-100.
[24] Qinggang DING，Qiucheng WU. Brief Analysis on therapy of TCM in the Treat-ment of Senile Dyslipidemia [J]. Chinese Medicine Modern Distance Education of China，2015.
[25] Kim YJ，Shin YO，Ha YW，et al. Anti-obesity Effect of Pinellia ternata Extract in Zucker Rats（Pharmacognosy）[J]. Bio Pharm Bull，2006，29 （6）：1278-1281.
[26] 范冬冬，匡艳辉，向世勰，等.绞股蓝化学成分及其药理活性研究进展[J].中国药学杂志，2017，52（5）：342-352.
[27] 周红坚，周园媛.氧化应激与线粒体功能障碍和胰岛素抵抗的关系[J].中国临床医生，2013，8（8）：17.
[28] Backhed F，Ding H，Wang T，et al. The gut microbiota as an environmental factor that regulates fat storage [J]. Proc Natl Acad Sci U S A，2004，101（44）：15718-15723.
[29] 陈卫红，苑晓琳，汪云，等.肠道菌群与肥胖关系的研究进展[J].中国食品卫生杂志，2015，27（4）：474.
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