Effects of Esomeprazole combined with Shugan Hewei Anshen Prescription on sleep quality and gastrointestinal hormones in patients with refractory gastroesophageal reflux disease with syndrome of heat stagnation in liver and stomach
SHEN Ding1 YE Wei2▲
1.The Third Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang Province, Hangzhou 310007, China;
2.Department of Gastroenterology, Hangzhou Traditional Chinese Medicine Hospital Affiliated to the Zhejiang Chinese Medical University, Zhejiang Province, Hangzhou 310007, China
Abstract：Objective To investigate the effects of Esomeprazole combined with Shugan Hewei Anshen Prescription on sleep quality and gastrointestinal hormone in patients with refractory gastroesophageal reflux disease with syndrome of heat stagnation in liver and stomach. Methods A total of 120 patients receiving treatment for refractory gastroesophageal reflux disease in Hangzhou Traditional Chinese Medicine Hospital Affiliated to the Zhejiang Chinese Medical University from June 2021 to June 2022 were selected and divided into traditional Chinese medicine group, western medicine group, and combined group according to random number table method, with 40 cases in each group. The traditional Chinese medicine group was given Shugan Hewei Anshen Prescription; the western group was given Esomeprazole; the combination group was given Esomeprazole combined with Shugan Hewei Anshen Prescription, and the three groups were treated for eight weeks. The traditional Chinese medicine syndrome score level was evaluated, the scavenging time, acid reflux times, post-reflux swallow-induced peristaltic wave (PSPW) index, and the levels of motilin (MTL), gastrin (GAS), and vasoactive intestinal peptide (VIP) were detected. The Pitts-burgh sleep quality index (PSQI) was used to assess sleep quality. Results After treatment, the acid reflux score, the retrosternal burning pain score, the irritability score, the two-side swelling score, the scavenging time of food mass, the acid reflux times, the PSPW index level, the VIP level, and the PSQI score of the three groups were lower than those before treatment, and the combined group was lower than the traditional Chinese medicine group and the western medicine group, and the differences were statistically significant (P＜0.05). After treatment, the MTL and GAS levels in the three groups were higher than those before treatment, and the combined group was higher than the traditional Chinese medicine group and western medicine group, and the differences were statistically significant (P＜0.05). Conclusion After combined treatment with Espromepazole, Shugan Hewei Anshen Prescription, traditional Chinese medicine syndrome integral level of patients with refractory gastroesophageal reflux disease with syndrome of heat stagnation in liver and stomach can be reduced, esophageal dynamic function can be restored, gastrointestinal hormone levels can be improved and sleep quality can be improved.
沈鼎1 叶蔚2▲. 艾司奥美拉唑联合疏肝和胃安神方对肝胃郁热型难治性胃食管反流病患者睡眠质量、胃肠激素的影响[J]. 中国医药导报, 2023, 20(12): 146-150.
SHEN Ding1 YE Wei2▲. Effects of Esomeprazole combined with Shugan Hewei Anshen Prescription on sleep quality and gastrointestinal hormones in patients with refractory gastroesophageal reflux disease with syndrome of heat stagnation in liver and stomach. 中国医药导报, 2023, 20(12): 146-150.
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