Correlation between the level of thrombomodulin during pregnancy and postpartum vascular endothelial function in patients with preeclampsia
YANG Yawen1 ZHOU Qiaojuan2 ZHAO Ai1 SHAO Wen1▲
1.Department of Obstetrics, Huai’an First People’s Hospital, Jiangsu Province, Huai’an 223300, China;
2.Department of Ultrasonography, Huai’an First People’s Hospital, Jiangsu Province, Huai’an 223300, China
Abstract：Objective To study the correlation between the level of thrombomodulin (TM) during pregnancy and postpartum vascular endothelial function in patients with preeclampsia (PE). Methods A total of 108 PE patients in Huai’an First People’s Hospital, Jiangsu Province from February 2018 to February 2021 were selected. All patients were tested for TM levels during pregnancy, according to endothelial dependent flow mediated dilation value at six weeks postpartum, they were divided into abnormal vascular endothelial function group and normal vascular endothelial function group. The influencing factors of postpartum vascular endothelial dysfunction were analyzed, and the predictive value of TM on vascular endothelial function was evaluated by receiver operating characteristic curve. Results Systolic blood pressure (SBP), diastolic blood pressure (DBP), homocysteine (Hcy), hypersensitive C-reactive protein (hs-CRP), and TM in abnormal vascular endothelial function group were higher than those in normal vascular endothelial function group (P＜0.05). TM level during pregnancy was negatively correlated with vascular endothelial function in PE patients (r=-0.416, P＜0.05). SBP, DBP, hs-CRP, and TM were the influencing factors of vascular endothelial function (OR=3.592, 2.641, 4.675, 3.872，P＜0.05). The cut-off value of TM during pregnancy for predicting postpartum vascular endothelial dysfunction was 44.87 μg/L, area under the curve was 0.865, sensitivity was 85.11%, and specificity was 83.61%. Conclusion The TM level of PE patients during pregnancy is closely related to postpartum vascular endothelial function, which can provide reasonable basis for clinical diagnosis and treatment.
杨亚文1 周巧娟2 赵爱1 邵雯1▲. 子痫前期患者孕期血栓调节蛋白水平与产后血管内皮功能的相关性[J]. 中国医药导报, 2023, 20(12): 111-114.
YANG Yawen1 ZHOU Qiaojuan2 ZHAO Ai1 SHAO Wen1▲. Correlation between the level of thrombomodulin during pregnancy and postpartum vascular endothelial function in patients with preeclampsia. 中国医药导报, 2023, 20(12): 111-114.
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