Abstract：Objective To investigate the effect of Bushen Jianpi Zhuanggu Decoction on spinal compression fracture. Methods Sixty patients with single vertebral compression fracture admitted to Department of Orthopedics, Jiading District Hospital of Traditional Chinese Medicine, Shanghai from March 2019 to May 2021 were selected and divided into treatment group (percutaneous vertebral cement injection combined with oral administration of Bushen Jianpi Zhuanggu Decoction, oral administration of traditional Chinese medicine for four weeks) and control group (percutaneous vertebral cement injection only), with 30 cases in each group. Visual analog scale (VAS) score, Japanese Orthopaedic Association (JOA) low back pain score, and Cobb angle of the two groups were observed before surgery and one week, three months after surgery, and the effects of the two groups and the changes of bone metabolism indexes before treatment and three months after surgery were compared. Adverse reactions during treatment were recorded in both groups. Results VAS score and Cobb angle at one week and three months after surgery were lower than those before surgery, JOA low back pain score was higher than that before surgery, VAS score and Cobb angle at three months after surgery were lower than those at one week after surgery, JOA low back pain score was higher than that at one week after surgery, the differences were statistically significant (P＜0.05). The VAS score and Cobb angle of the treatment group at one week and three months after surgery were lower than those of the control group at the same points, and the JOA low back pain score was higher than that of the control group at the same time points, the differences were statistically significant (P＜0.05). Three months after surgery, the levels of osteocalcin (OCN) and bone alkaline phosphatase (BALP) were higher than those before surgery, and the level of human cross-linked carboxy-terminal peptide (CTX) was lower than that before surgery, the OCN and BALP of treatment group were higher than those of control group, and CTX was lower than that of control group, the differences were statistically significant (P＜0.05). The therapeutic effect of the treatment group was better than that of the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Bushen Jianpi Zhuanggu Decoction combined with vertebral bone cement injection in the treatment of spinal compression fracture has an ideal effect on the improvement of lumbago and function, and the improvement of bone metabolism is more obvious.
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