Role of long non-coding RNA-NEF in the genesis and development of hepatocellular carcinoma, gastric carcinoma, and esophageal carcinoma
JIA Ganggang LI Bin LU Lixia YU Xiaohui
Department of Gastroenterology, the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Gansu Province, Lanzhou 730050, China
Abstract：Long non-coding RNA (lncRNA) are a class of RNAs＞200 nucleotides in length that do not encode proteins. They regulate gene expression by interacting with RNA and DNA, and their functions are closely related to subcellular localization. In the nucleus, lncRNA regulate gene expression at the epigenetic and transcriptional levels, and in the cytoplasm, it regulate gene expression at the post-transcriptional and translational levels. As a kind of exosome, the abnormal expression of lncRNA has been confirmed to have tumor inhibition or carcinogenic effect, and play an important role in the biological processes of tumor proliferation, apoptosis, immune escape, and so on. LncRNA-NEF is a newly discovered lncRNA in liver cancer, which can inhibit epithelial mesenchymal transformation and metastasis of liver cancer. Follow-up studies have found that lncRNA-NEF plays a role in a variety of tumors, mainly manifested as a cancer suppressor. The incidence of malignant tumor of digestive system is high, the prognosis is poor and the survival time is short. In this paper, the main characteristics of lncRNA-NEF and the progress of its role in liver cancer, gastric cancer, and esophageal cancer were reviewed, in order to provide a basis for the discovery of new tumor diagnostic markers and prognostic indicators, and provide new ideas for its treatment and explore new targets for tumor treatment.
贾刚刚 李斌 卢利霞 于晓辉. 长链非编码RNA-NEF在肝癌、胃癌、食管癌发生发展中的作用[J]. 中国医药导报, 2023, 20(12): 52-54.
JIA Ganggang LI Bin LU Lixia YU Xiaohui. Role of long non-coding RNA-NEF in the genesis and development of hepatocellular carcinoma, gastric carcinoma, and esophageal carcinoma. 中国医药导报, 2023, 20(12): 52-54.
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