Abstract：Objective To explore the distribution and drug resistance of pathogenic bacteria in children with acute abdomen complicated with severe infection. Methods A total of 100 children with acute abdomen complicated with severe infection admitted to Shuyang Hospital Affiliated to Xuzhou Medical University from January 2020 and January 2022 were selected as the research objects. The peritoneal effusion within 24 hours after admission was collected and the peritoneal effusion samples were isolated and cultured according to the national clinical examination operation procedures. The full-automatic bacterial identification/drug sensitivity system was used to monitor the species of infectious pathogens, and the K-B disk diffusion method was used to complete the drug sensitivity test analysis with reference to the Chinese medicine sensitivity test standard of the American Society for Clinical Laboratory Standards Institute. Results A total of 113 pathogenic bacteria were isolated from 100 cases of acute abdomen complicated with severe infection, including 25 Gram-positive bacteria (22.12%), 86 Gram-negative bacteria (76.11%), and 2 fungi (1.78%). The resistance of Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa to Gentamicin, Ceftazidime, Ampicillin, Piperacillin / Tazobactam were all ＞50%. Sensitive to Imipenem and Aztreonam; there was no significant difference in the drug resistance rates of Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa in different years (P＞0.05). Conclusion The children with acute abdomen complicated with severe infection are mainly infected by gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa, but they have not shown obvious changes in drug resistance in the past two years. Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa still have high sensitivity to Imipenem, Aztreonam and other antibiotics.
任船 葛荣忠 丁辉 . 急腹症合并重症感染患儿病原菌分布及耐药性分析[J]. 中国医药导报, 2023, 20(10): 149-151,155.
REN Chuan GE Rongzhong DING Hui. Distribution and drug resistance of pathogenic bacteria in children with acute abdomen complicated with severe infection. 中国医药导报, 2023, 20(10): 149-151,155.
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