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18F-FDG PET/CT在肺部磨玻璃结节良恶性鉴别诊断中的应用价值
李忠1   吉勇2   王佼1   李琦3   陈渝1   付尚志4   谢祥先2   敖秋红1   王真辉1   文明3
1.重庆华健友方医院医学影像科,重庆   400052;
2.重庆华健友方医院外科,重庆   400052;
3.重庆医科大学附属第一医院放射科,重庆   400016;
4.重庆华健友方医院肿瘤科,重庆   400052
Application value of 18F-FDG PET/CT in differential diagnosis of benign and malignant pulmonary ground glass nodules
LI Zhong1   JI Yong2   WANG Jiao1   LI Qi3   CHEN Yu1   FU Shangzhi4   XIE Xiangxian2   AO Qiuhong1   WANG Zhenhui1   WEN Ming3
1.Department of Medical Imaging, Chongqing Huajianyoufang Hospital, Chongqing   400052, China; 
2.Department of Surgery, Chongqing Huajianyoufang Hospital, Chongqing   400052, China; 
3.Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing   400016, China; 
4.Department of Oncology, Chongqing Huajianyoufang Hospital, Chongqing   400052, China
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摘要 目的 探讨18F-氟代脱氧葡萄糖正电子发射断层显像/计算机体层成像仪(18F-FDG PET/CT)在肺部磨玻璃结节(GGN)良恶性鉴别中的应用价值。 方法 选择重庆华健友方医院2016年2月至2021年4月具有完整18F- FDG PET/CT影像资料且经手术或穿刺活检病理证实60例患者[63个GGN(直径≥5 mm)]。分析病灶的形态学表现,并计算病灶的最大标准摄取值(SUVmax)。 结果63个GGN中混合性GGN(mGGN)38个(良性7个、恶性31个),纯GGN(pGGN)25个(良性12个、恶性13个)。恶性GGN中腺癌40个、鳞癌2个、腺鳞癌2个;良性GGN中炎症12个、结核6个、肺泡上皮不典型增生1个。良恶性GGN病灶大小、边缘、密度比较,差异有统计学意义(P<0.05);良恶性GGN病灶位置比较,差异无统计学意义(P>0.05)。良恶性mGGN中SUVmax≥1.0比较,差异有统计学意义(P<0.05);良恶性pGGN中SUVmax≥1.0比较,差异无统计学意义(P>0.05)。结论 18F-FDG PET/CT在肺部GGN良恶性鉴别诊断中能够提供影像及代谢信息,具有重要临床价值。

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李忠1 吉勇2 王佼1 李琦3 陈渝1 付尚志4 谢祥先2 敖秋红1 王真辉1 文明3
关键词 氟代脱氧葡萄糖正电子发射计算机断层显像/计算机体层成像仪肺磨玻璃结节鉴别诊断
    
Abstract:Objective To explore the application value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in the differrentiation of benign and malignant pulmonary ground glass nodules (GGN). Methods Sixty patients (63 GGN [diameter ≥5 mm]) with complete 18F-FDG PET/CT image data and pathologically confirmed by surgery or puncture biopsy were selected from Chongqing Huajianyoufang Hospital from February 2016 to April 2021. The morphological manifestations of the lesions were analyzed, and maximum standard uptake value (SUVmax) of lesions were calculated. Results Among the 63 GGN, 38 were mixed GGN (7 benign and 31 malignant), and 25 were pure GGN (12 benign and 13 malignant). There were 40 adenocarcinoma, 2 squamous cell carcinoma, and 2 adenosquamous cell carcinoma in malignant GGN. There were 12 inflammation, 6 tuberculosis, and 1 atypical hyperplasia of alveolar epithelium in benign GGN. There were significant differences in the size, margin, and density of benign and malignant GGN lesions (P<0.05); there was no significant difference in GGN location between benign and malignant (P>0.05). SUVmax≥1.0 in benign and malignant mGGN was statistically significant (P<0.05); there was no statistical significance in SUVmax≥1.0 between benign and malignant pGGN (P>0.05). Conclusion 18F-FDG PET/CT can provide imaging and metabolic information in the differential diagnosis of benign and malignant pulmonary GGN, which has important clinical value.
Key wordsFluorodeoxyglucose    Positron emission tomography/computed tomography    Pulmonary ground glass nodules    Differential diagnosis
    
基金资助:重庆市九龙坡区科技计划项目(2019-02-011-Z);
重庆市科卫联合医学科研项目(2022MSXM147)。
作者简介: 李忠(1972.10-),男,硕士,副主任医师;研究方向:早期肺癌影像诊断。
引用本文:   
李忠1 吉勇2 王佼1 李琦3 陈渝1 付尚志4 谢祥先2 敖秋红1 王真辉1 文明3. 18F-FDG PET/CT在肺部磨玻璃结节良恶性鉴别诊断中的应用价值[J]. 中国医药导报, 2023, 20(10): 134-137.
LI Zhong1 JI Yong2 WANG Jiao1 LI Qi3 CHEN Yu1 FU Shangzhi4 XIE Xiangxian2 AO Qiuhong1 WANG Zhenhui1 WEN Ming3. Application value of 18F-FDG PET/CT in differential diagnosis of benign and malignant pulmonary ground glass nodules. 中国医药导报, 2023, 20(10): 134-137.
链接本文:  
https://www.yiyaodaobao.com.cn/CN/10.20047/j.issn1673-7210.2023.10.30     或     https://www.yiyaodaobao.com.cn/CN/Y2023/V20/I10/134

 

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