Association of tumor necrosis factor-α, high mobility group box-1 protein, and high sensitivity C-reactive protein with trauma-induced coagulopathy in patients
YANG Yanhong1 YUE Huan2 QIN Yong1▲
1.Department of Emergency, Fuling Hospital Affiliated to Chongqing University, Chongqing 408000, China;
2.the First Department of Orthopaedics, Fuling Hospital Affiliated to Chongqing University, Chongqing 408000, China
Abstract：Objective To investigate the association between tumor necrosis factor-α (TNF-α), high mobility group box-1 protein (HMGB1), and high sensitivity C-reactive protein (hs-CRP) with trauma-induced coagulopathy (TIC) in patients. Methods A total of 120 patients with acute trauma admitted to Fuling Hospital Affiliated to Chongqing University from July 2020 to July 2022 were selected and divided into TIC group (39 cases) and non-TIC group (81 cases) according to the incidence of TIC. The difference of clinical data between the two groups was compared. Multivariate logistic regression model was used to analysis the relationship between TNF-α, HMGB1, and hs-CRP and the occurrence of TIC. Receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of TNF-α, HMGB1, and hs-CRP for the occurrence of TIC. Results The injury severity score (ISS), shock index (SI), and levels of TNF-α, HMGB1, hs-CRP in TIC group were higher than those in non-TIC group (P＜0.05). Multivariate analysis showed that SI (OR=1.545, 95%CI: 1.100-2.170), TNF-α (OR=1.021, 95%CI: 1.008-1.034), HMGB1 (OR=1.068, 95%CI: 1.025-1.113), hs-CRP (OR=1.047, 95%CI: 1.012-1.083) were the influencing factors of TIC occurrence (P＜0.05). ROC curve analysis showed that the area under the curve of TNF-α, HMGB1, and hs-CRP combined to predict TIC occurrence was 0.900, the sensitivity was 0.923, and the specificity was 0.753. Conclusion TNF-α, HMGB1, and hs-CRP are factors affecting the occurrence of TIC in patients, and can be used as serum biomarkers for early screening of TIC.
杨延红1 乐欢2 秦勇1▲. 肿瘤坏死因子-α、高速泳动族蛋白B1及超敏C反应蛋白与急性创伤患者发生创伤性凝血病的关系[J]. 中国医药导报, 2023, 20(10): 88-91.
YANG Yanhong1 YUE Huan2 QIN Yong1▲. Association of tumor necrosis factor-α, high mobility group box-1 protein, and high sensitivity C-reactive protein with trauma-induced coagulopathy in patients. 中国医药导报, 2023, 20(10): 88-91.
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