Influence of vitamin D assisted reduced glutathione on hepatic lipidosis and intestinal flora in patients with type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease
Abstract：Objective To investigate the effect of vitamin D assisted reduced glutathione in the treatment of type 2 diabetes mellitus (T2DM) complicated with non-alcoholic fatty liver disease (NAFLD) and its influence on hepatic lipidosis and intestinal flora. Methods A total of 168 patients with T2DM complicated with NAFLD admitted to the Department of Endocrinology of the First People’s Hospital of Kashgar, Xinjiang Uygur Autonomous Region from July 2019 to October 2020 were selected as the study objects. According to the random number table method, they were divided into control group and observation group, with 84 cases in each group. The control group received conventional treatment and reduced glutathione, and the observation group received vitamin D assisted therapy on the basis of the control group. The treatment course of both groups was three months. The efficacy of NAFLD was compared between the two groups, and the liver function, liver fat deposition, intestinal flora, and blood glucose indexes before and after treatment were compared between the two groups. Results There were two cases in the control group and four cases in the observation group during the treatment. The efficacy of NAFLD in the observation group was better than that in the control group (P＜0.05). After treatment, glutamic pyruvic transaminase (GPT), glutamic oxaloacetic aminotransferase (GOT), γ-glutamyltransferase (GGT), controlled attenuation parameter (CAP), liver stiffness measurement (LSM), liver fat content, and levels of Escherichia coli, fasting blood glucose (FPG), 2 h postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c) of two groups were lower than those before treatment, while levels of Bifidobacterium and Lactobacillus in two groups were higher than those before treatment (P＜0.05). After treatment, GPT, GOT, GGT, CAP, LSM, liver fat content, and levels of Escherichia coli, FPG, 2hPG, HbA1c in observation group were lower than those in control group, while levels of Bifidobacterium and Lactobacillus were higher than those in control group (P＜0.05). Conclusion Vitamin D-assisted reduced glutathione has a good effect in the treatment of T2DM patients with NAFLD, which can improve clinical effect, improve liver function, reduce liver lipidosis, and regulate intestinal flora.
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