Correlation between miR129-1 expression level in peripheral blood and prognosis in patients with non-small cell lung cancer
ZHANG Cong1 TIAN Qin2 DAI Dongmei3 HAN Dousheng1▲
1.Department of the First Outpatient, the 960 Hospital of Chinese People’s Liberation Army, Shandong Province, Jinan 250002, China;
2.Department of Oncology, Shandong Provincial Third Hospital, Shandong Province, Jinan 250013, China;
3.Department of Tumor Radiotherapy, the 960th Hospital of Chinese People’s Liberation Army, Shandong Province, Jinan 250002, China
Abstract：Objective To analyze the correlation between the miR129-1 expression level in peripheral blood and prognosis in patients with non-small cell lung cancer (NSCLC). Methods A total of 109 patients with NSCLC admitted to the 960th Hospital of Chinese People’s Liberation Army and followed up for three years from January to December 2017 were selected as the study objects. According to the prognosis, they were divided into death group and survival group. The clinical case characteristics of the two groups were compared, and the factors influencing the prognosis of NSCLC patients were analyzed. The survival of patients with low and high expression of miR129-1 in peripheral blood was compared. Results Of the 109 patients, seven were lost to follow-up, 37 died, and 65 survived among the remaining 102 patients. The proportion of smoking history, lymph node metastasis, low differentiation, stage Ⅲ, and low expression of miR129-1 in peripheral blood in the death group was higher than those in the survival group, the differences were statistically significant (P＜0.05). Multivariate analysis showed that lymph node metastasis, degree of differentiation, clinical stage, and peripheral blood miR129-1 expression were all influencing factors of prognosis in NSCLC patients (P＜0.05). The 3-year survival rate of patients with low expression of miR129-1 in peripheral blood was lower than that of patients with high expression, and the difference was statistically significant (P＜0.05). Conclusion Peripheral blood miR129-1 expression level is closely related to the prognosis of patients with NSCLC and is expected to be a biomarker for the diagnosis and treatment of NSCLC.
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