非小细胞肺癌患者外周血中miR129-1表达水平与预后的相关性

doi:10.20047/j.issn1673-7210.2023.08.23

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摘要目的分析非小细胞肺癌（NSCLC）患者外周血中miR129-1表达水平与预后的相关性。方法选择2017年1月至12月解放军第九六〇医院收治并随访3年的109例NSCLC患者为研究对象，据预后情况将其分为死亡组与存活组。比较两组临床病例特征，分析NSCLC患者预后的影响因素。采用生存曲线比较外周血miRNA129-1低表达患者与高表达患者的生存情况。结果 109例患者失访7例，剩余102例中死亡37例，生存65例。死亡组吸烟史、淋巴结转移、低分化、Ⅲ期、外周血miR129-1低表达占比高于生存组，差异有统计学意义（P＜0.05）。多因素分析显示，淋巴结转移、分化程度、临床分期、外周血miR129-1表达情况均为NSCLC患者预后的影响因素（P＜0.05）。外周血miR129-1低表达患者3年生存率低于高表达患者，差异有统计学意义（P＜0.05）。结论外周血miR129-1表达水平与NSCLC患者预后密切相关，有望成为NSCL诊疗的生物标志物。

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	张聪1 田芹2 戴冬梅3 韩斗升1▲

关键词 ： miR129-1, 非小细胞肺癌, 外周血, 预后, 相关性

Abstract：Objective To analyze the correlation between the miR129-1 expression level in peripheral blood and prognosis in patients with non-small cell lung cancer (NSCLC). Methods A total of 109 patients with NSCLC admitted to the 960th Hospital of Chinese People’s Liberation Army and followed up for three years from January to December 2017 were selected as the study objects. According to the prognosis, they were divided into death group and survival group. The clinical case characteristics of the two groups were compared, and the factors influencing the prognosis of NSCLC patients were analyzed. The survival of patients with low and high expression of miR129-1 in peripheral blood was compared. Results Of the 109 patients, seven were lost to follow-up, 37 died, and 65 survived among the remaining 102 patients. The proportion of smoking history, lymph node metastasis, low differentiation, stage Ⅲ, and low expression of miR129-1 in peripheral blood in the death group was higher than those in the survival group, the differences were statistically significant (P＜0.05). Multivariate analysis showed that lymph node metastasis, degree of differentiation, clinical stage, and peripheral blood miR129-1 expression were all influencing factors of prognosis in NSCLC patients (P＜0.05). The 3-year survival rate of patients with low expression of miR129-1 in peripheral blood was lower than that of patients with high expression, and the difference was statistically significant (P＜0.05). Conclusion Peripheral blood miR129-1 expression level is closely related to the prognosis of patients with NSCLC and is expected to be a biomarker for the diagnosis and treatment of NSCLC.

Key words： MiR129-1 Non-small cell lung cancer Peripheral blood Prognosis Relevance

基金资助:山东省自然科学基金资助项目（ZR2020MA053）。

通讯作者: ▲通讯作者

作者简介: 张聪（1985.11-），女，硕士；研究方向：肿瘤的综合治疗。

引用本文:

张聪1 田芹2 戴冬梅3 韩斗升1▲. 非小细胞肺癌患者外周血中miR129-1表达水平与预后的相关性[J]. 中国医药导报, 2023, 20(8): 103-106.
ZHANG Cong1 TIAN Qin2 DAI Dongmei3 HAN Dousheng1▲. Correlation between miR129-1 expression level in peripheral blood and prognosis in patients with non-small cell lung cancer. 中国医药导报, 2023, 20(8): 103-106.

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