Abstract：The incidence of human epidermal growth factor receptor 2 (HER2) variants is low in patients with metastatic colon cancer (mCRC), and there is no uniform standard for detection methods. HER2 mutations can lead to resistance to anti-epidermal growth factor receptor-targeted therapy in mCRC. Single anti-HER2-targeted therapy has limited effect, however, dual anti-HER2-targeted therapy such as Trastuzumab combined with Lapatinib or Pertuzumab has shown good anti-tumor efficacy in mCRC. This article aims to review the detection, clinicopathological features, predictive value, and treatment strategies, and prospects of HER2 in mCRC.
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