Effects of Parecoxib Sodium advanced analgesia at different time points on analgesia and narcotic dosage after shoulder arthroscopic rotator cuff repair
ZHOU Yufa LIU Zhengyuan QIU Jun
Department of Anesthesiology, Li Huili Hospital, Ningbo Medical Center, Zhejiang Province, Ningbo 315000, China
Abstract：Objective To investigate the effects of Parecoxib Sodium on advanced analgesia at different time points on analgesia and narcotic dosage after shoulder arthroscopic rotator cuff repair. Methods A total of 177 patients with shoulder arthroscopic rotator cuff repair who were admitted to Li Huili Hospital, Ningbo Medical Center, Zhejiang Province from April to December 2021 were selected, they were divided into group A (40 mg of Parecoxib Sodium was given 10 min before anesthesia induction, and normal saline was given 10 min before the end of surgery, 59 cases), group B (normal saline was given 10 min before anesthesia induction, and 40 mg of Parecoxib Sodium was given 10 min before the end of surgery, 59 cases), and group C (normal saline was given 10 minutes before anesthesia induction and 10 minutes before the end of surgery, 59 cases). The use of Remifentanil was compared among three groups; visual analogue scale (VAS) scores of three groups were compared 1 h before surgery, and 3 and 6 h after surgery; the number of self-controlled analgesia compressions 24 h after surgery and the amount of Fentanyl were compared among the three groups, and the occurrence of adverse reactions in three groups was recorded. Results The dosage of Remifentanil in group A was lower than that in groups B and C, and the differences were statistically significant (P＜0.05). The pairwise comparison of VAS scores at different time points in group A and B showed statistically significant differences (P＜0.05). The VAS score of group A was lower than that of group B and C at 3 and 6 h after surgery; VAS score of group B was lower than that of group C, and the differences were statistically significant (P＜0.05). The number of self-controlled analgesia compressions and the amount of Fentanyl in group A and B were lower than those in group C 24 h after surgery; the number of self-controlled analgesia compressions 24 h after surgery and the amount of Fentanyl in group A were lower than those in group B, and the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of postoperative adverse reactions among three groups (P＞0.05). Conclusion Preanalgesia with Parecoxib Sodium before anesthesia induction can relieve postoperative pain, reduce the number of patient-controlled analgesia compressions 24 h after surgery and the amount of Fentanyl after surgery, and it is safe and reliable.
周余发 刘正元 邱珺. 不同时间点帕瑞昔布钠超前镇痛对肩关节镜肩袖修复术后镇痛及麻醉药量的影响[J]. 中国医药导报, 2023, 20(7): 123-126.
ZHOU Yufa LIU Zhengyuan QIU Jun. Effects of Parecoxib Sodium advanced analgesia at different time points on analgesia and narcotic dosage after shoulder arthroscopic rotator cuff repair. 中国医药导报, 2023, 20(7): 123-126.
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