Influence of massage manipulation on anxiety disorder and γ-aminobutyric acid expression level after opioid addiction
LI Shuxiu1 SHI Ningning2
1.College of Acupuncture, Moxibustion, and Massage, Gansu University of Chinese Medicine, Gansu Province, Lanzhou 730000, China;
2.Department of Massage, Gansu Provincial Hospital of Traditional Chinese Medicine, Gansu Province, Lanzhou 730050, China
Abstract：Objective To explore the influence of massage manipulation on anxiety disorder and γ-aminobutyric acid expression level after opioid addiction. Methods From July 2020 to January 2021, 74 patients with post-addiction anxiety disorder entered the Gansu Women’s Compulsory Isolation Drug Rehabilitation Center and Lanzhou Compulsory Isolation Drug Rehabilitation Center at the same detoxication stage were selected and divided into routine detoxification group (37 cases) and massage manipulation group (37 cases) by random number table method. The intervention time was three months. The clinical efficacy of two groups was compared. The Hamilton anxiety scale (HAMA) scale score, somatic anxiety factor score, mental anxiety factor score, and γ-aminobutyric acid level were analyzed and compared between the two groups before and after the intervention. Results One case dropped out of the routine detoxification group during the study. The clinical effect of massage manipulation group was better than that of routine detoxification group, and the difference was statistically significant (P＜0.05). After treatment, the HAMA total score, somatic anxiety score, and mental anxiety score of the two groups were lower than those before treatment, and the massage manipulation group was lower than the conventional detox group, the differences were statistically significant (P＜0.05). After treatment, the level of γ-aminobutyric acid in massage manipulation group was higher than that in massage manipulation group before treatment, and the difference was statistically significant (P＜0.05). Conclusion Chinese massage can activate the expression of endogenous neurotransmitter γ-aminobutyric acid in patients with opioid addiction anxiety disorder, relieve their anxiety symptoms and reduce the desire for drugs.
李淑秀1 师宁宁2. 推拿手法对阿片类药物成瘾后焦虑症及γ-氨基丁酸表达水平的影响[J]. 中国医药导报, 2023, 20(7): 93-96.
LI Shuxiu1 SHI Ningning2. Influence of massage manipulation on anxiety disorder and γ-aminobutyric acid expression level after opioid addiction. 中国医药导报, 2023, 20(7): 93-96.
[1] Mennin DS，Fresco DM，Ritter M，et al. An open trial of emotion regulation therapy for generalized anxiety disorder and cooccurring depression [J]. Depress Anxiety，2015，32（8）：614-623.
[2] Stein DJ，Scott KM，de Jonge P，et al. Epidemiology of anxiety disorders：from surveys to nosology and back [J]. Dialogues Clin Neurosci，2017，19（2）：127-136.
[3] 陈娟，高颖.肌肉放松技术对苯二氮■类药物依赖性焦虑症患者负面情绪及生活质量的影响[J].广西医科大学学报，2017，34（2）：310-314.
[4] 张盼盼，徐文锦，刘惠芬.中枢神经系统ERK信号通路在药物成瘾中的作用机制研究进展[J].中国药理学通报，2017，33（1）：1-9.
[5] Babaev O，Piletti Chatain C，Krueger-Burg D. Inhibition in the amygdala anxiety circuitry [J]. Exp Mol Med，2018，50（4）：1-16.
[6] Nader DA，Sanchez ZM. Effects of regular cannabis use on neurocognition，brain structure，and function：a systematic review of findings in adults [J]. Am J Drug Alcohol Abuse，2018，44（1）：4-18.
[7] 周会婷，邓刚，刘晓军，等.毒品成瘾者焦虑与复吸：自我不和谐与吸毒动机的链式中介作用[J].中国药物依赖性杂志，2019，28（1）：54-58.
[8] 师宁宁，李文涛，罗盘山.中医按摩戒毒康复技术对戒毒人员心理问题的疗效评价[J].心理月刊，2020，15（19）：98-100.
[9] 王纯庠，江国荣，张露蓉，等.中医药整体序贯疗法改善阿片类药物成瘾稽延期戒断症状疗效及其对相关神经递质影响研究[J].中国药物滥用防治杂志，2010，16（1）：12- 16.
[10] 美国精神医学学会，张道龙.精神障碍诊断与统计手册[M].北京：北京大学出版社，2016.
[11] 甘肃省戒毒管理局.DB62/T2965-2019 中医按摩戒毒康复技术规范[S].甘肃：甘肃省市场监督管理局，2019.
[12] 雷斯媛，庆慧，崔伟峰，等.针药结合为主的综合疗法治疗焦虑症276例疗效分析[J].时珍国医国药，2019，30（8）：1903-1904.
[13] 王倩，包永欣.穴位本态探析[J].中医杂志，2018，59（9）：728-732.
[14] 彭旭明，范志勇，黄勇，等.一指禅推法作用于胆肾经原穴的脑功能磁共振研究[J].辽宁中医药大学学报，2015， 17（7）：74-78.
[15] 赵阳，于晓宇，尹洪菊，等.艾灸百会穴联合自拟郁金方治疗脑梗塞后抑郁症的疗效及作用机理[J].中华中医药学刊，2017，35（9）：2252-2254.
[16] 刘丽莎，董宝强，刘旭来，等.针刺三阴交、神门、内关对失眠大鼠下丘脑5-HT含量及Glu/GABA比值影响机制的探究[J].中华中医药学刊，2022，40（3）：65-68.
[17] Famitafreshi H，Karimian M. Reduction of anxiety level is associated with an oxidative-stress imbalance in the hippocampus in morphine administration period in male rats [J]. J Addict Dis，2020，38（1）：64-70.
[18] Latif ZE，?譒altyte Benth J，Solli KK，et al. Anxiety，depression，and insomnia among adults with opioid dependence treated with extended-release naltrexone vs buprenorphine-naloxone：a randomized clinical trial and follow-up study [J]. JAMA Psychiatry，2019，76（2）：127-134.
[19] Motaghinejad M，Karimian SM，Motaghinejad O，et al. The effect of various morphine weaning regimens on the sequelae of opioid tolerance involving physical dependency，anxiety and hippocampus cell neurodegeneration in rats [J]. Fundam Clin Pharmacol，2015，29（3）：299-309.
[20] Rogers AH MA，Kauffman BY MA，Bakhshaie J MD，et al. Anxiety sensitivity and opioid misuse among opioid-using adults with chronic pain [J]. Am J Drug Alcohol Abuse，2019，45（5）：470-478.
[21] 王玮，陈晶莹.tDCS对海洛因成瘾者慢性渴求及负性情绪的干预效果评价[J].中国药物依赖性杂志，2021，30（6）：424-427，434.
[22] Koob GF. Neurobiology of opioid addiction：opponent process，hyperkatifeia，and negative reinforcement [J]. Biol Psychiatry，2020，87（1）：44-53.
[23] Rosoff DB，Smith GD，Lohoff FW. Prescription opioid use and risk for major depressive disorder and anxiety and stress-related disorders：a multivariable mendelian randomization analysis [J]. JAMA Psychiatry，2021，78（2）：151-160.
[24] Ben Hamida S，Boulos LJ，McNicholas M，et al. Mu opioid receptors in GABAergic neurons of the forebrain promote alcohol reward and drinking [J]. Addict Biol，2019，24（1）：28-39.
[25] Przybysz KR，Werner DF，Diaz MR. Age-dependent regulation of GABA transmission by kappa opioid receptors in the basolateral amygdala of Sprague-Dawley rats [J]. Neuropharmacology，2017，117：124-133.
[26] Hauser SR，Hedlund PB，Roberts AJ，et al. The 5-HT7 receptor as a potential target for treating drug and alcohol abuse [J]. Front Neurosci，2015，8：448.
[27] Silverman RB. Design and mechanism of GABA aminotransferase inactivators.Treatments for epilepsies and addictions [J]. Chem Rev，2018，118（7）：4037-4070.
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