Research progress of epidermal growth factor receptor targeted therapy for cervical cancer
HAN Buwei1 LIU Yang1 LIU Ning1 HAO Xinying1 ZHOU Lina1 QI Ding1 YUAN Mengke1 LIU Li2
1.Graduate School, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
2.Ward Two， Department of Gynecology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China
Abstract：The occurrence of cervical cancer is generally associated with human papillomavirus (HPV) infection, and there was a strong correlation between HPV infection and epidermal growth factor receptor (EGFR) signaling cascade upregulation. Therefore, EGFR is commonly targeted and used to treat cervical cancer using tyrosine kinase inhibitors and monoclonal antibodies. This review aims to integrate contemporary approaches to EGFR-targeted therapy of cervical cancer and highlight the current differential roles of microRNA and associated genes in cervical cancer involving EGFR mutations. Potential resistance to existing EGFR therapies and the need for better therapies are reviewed and discussed with a view to developing novel agents with better efficacy.
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