Abstract：Objective To discuss the medication laws of simultaneous treatment for phlegm and blood stasis in treating atherosclerosis based on data mining. Methods The literatures of CNKI, Wanfang Data and VIP from January 2012 to March 2022 were retrieved. The prescription database was established. The drug efficacy, four nature, five flavors, and channel tropism medication laws had been sorted out. Association rules, cluster analysis, and complex network analysis were carried out. Results According to the inclusion and exclusion criteria, 63 prescriptions of traditional Chinese medicine and 124 flavors of traditional Chinese medicine were finally included. The drugs for the treatment of phlegm and blood stasis were mainly drugs for promoting blood circulation and resolving blood stasis, drugs for tonifying deficiency, and drugs for dissipating phlegm, relieving cough and asthma. The most commonly used medicine was bitter, and its nature was warm. The liver, lung and stomach channel were the main channel tropism. The association rule analysis and cluster analysis of high-frequency traditional Chinese medicine had formed 15 drug pair combinations and seven cluster combinations. The complex network analysis suggested that the core prescription of the treatment of phlegm and blood stasis was Danlou Tablets and Erchen Decoction plus or minus. Conclusion The basic means of simultaneous treatment for phlegm and blood stasis to treat atherosclerosis is activating blood and dissipating phlegm, combining with strengthen vital qi and tonify the deficiency, clear heat-dampness and promote digestion to enhance the effect of dissipating phlegm and removing blood stasis.
吴茜 李兰兰 曹琳琳 王师菡. 基于数据挖掘的痰瘀同治法治疗动脉粥样硬化的用药规律[J]. 中国医药导报, 2023, 20(6): 119-122,144.
WU Qian LI Lanlan CAO Linlin WANG Shihan. Medication laws of simultaneous treatment for phlegm and blood stasis in treating atherosclerosis based on data mining. 中国医药导报, 2023, 20(6): 119-122,144.
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