B族溶血性链球菌带菌孕妇不同分娩方式对新生儿感染的影响及相关影响因素分析

doi:10.20047/j.issn1673-7210.2023.06.23

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摘要目的探讨B族溶血性链球菌（GBS）带菌孕妇不同分娩方式对新生儿感染的影响及相关影响因素分析。方法分析2017年1月至2018年12月在首都医科大学附属北京妇产医院产检并分娩的1 376例妊娠足月GBS带菌孕妇的临床资料。根据分娩方式不同分为阴道分娩组及剖宫产组，按照新生儿的感染情况将其分为GBS阳性组和GBS阴性组。分析不同分娩方式下新生儿GBS感染情况及其影响因素。结果经阴道分娩孕妇999例，新生儿999例；剖宫产孕妇377例，新生儿388例。阴道分娩组中新生儿GBS阳性79例，剖宫产组新生儿GBS阳性12例；两组新生儿感染情况比较，差异有统计学意义（P＜0.05）。两组年龄、分娩孕龄、胎膜早破占比比较，差异无统计学意义（P＞0.05）；两组使用抗生素治疗占比比较，差异有统计学意义（P＜0.05）。产钳助产及自然分娩，使用青霉素和头孢唑啉是新生儿GBS感染的影响因素（P＜0.05）。结论妊娠晚期携带GBS的孕妇不同的分娩方式与新生儿GBS感染相关，产前使用抗生素可以降低新生儿GBS感染率。

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	张同庆王明赵轩宇姜海利

关键词 ： B族溶血性链球菌, 分娩方式, 垂直传播, 新生儿感染

Abstract：Objective To explore the effects of different delivery mode on neonatal infection in pregnant women with group B streptococcus (GBS) and to analyzed of related influencing factors. Methods Retrospective study was conducted on the clinical data of 1 376 pregnant women with GBS bacteria during pregnancy and delivery in Beijing Obstetrics and Gynecology Hospital, Capital Medical University from January 2017 to December 2018. According to different delivery methods, they were divided into vaginal delivery group and cesarean section group, and according to the infection of newborns, they were divided into GBS positive group and GBS negative group. GBS infection and its influencing factors in neonates under different delivery mode were analyzed. Results There were 999 pregnant women and 999 newborns delivered vaginally; there were 377 pregnant women and 388 newborns during cesarean section. There were 79 positive cases of GBS in vaginal delivery group and 12 positive cases in cesarean section group; there was statistical significance in neonatal infection between two groups (P＜0.05). There were no significant differences in age, gestational age at delivery, proportion of premature rupture of membranes between two groups (P＞0.05); there was statistical significance in the proportion of antibiotic treatment between two groups (P＜0.05). Forceps assisted labor and natural delivery, the use of Penicillin and Cefazolin was influencing factors for neonatal GBS infection (P＜0.05). Conclusion Different delivery modes of pregnant women with GBS in the third trimester of pregnancy are related to neonatal GBS infection, and application of antibiotics can reduce the incidence of neonatal GBS infection.

Key words： Group B Streptococcus Delivery mode Vertical transmission Neonatal infection

基金资助:北京市优秀人才培养资助项目（2015000021469 G215）。

通讯作者: 姜海利（1980.4-），男，医学博士；研究方向：围生期感染、胎儿医学、产前诊断。

作者简介: 张同庆（1989.6-），男，硕士；研究方向：围生期感染、母胎医学。

引用本文:

张同庆王明赵轩宇姜海利. B族溶血性链球菌带菌孕妇不同分娩方式对新生儿感染的影响及相关影响因素分析[J]. 中国医药导报, 2023, 20(6): 104-107.
ZHANG Tongqing WANG Ming ZHAO Xuanyu JIANG Haili. Effects of different delivery mode on neonatal infection in pregnant women with group B streptococcus and analysis of related influencing factors. 中国医药导报, 2023, 20(6): 104-107.

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https://www.yiyaodaobao.com.cn/CN/10.20047/j.issn1673-7210.2023.06.23 或 https://www.yiyaodaobao.com.cn/CN/Y2023/V20/I6/104

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