Abstract：Objective To investigate the clinical effect of Tongluo Zhitong Gel in the treatment of early-middle stage of knee osteoarthritis (KOA). Methods Sixty patients with early-middle stage KOA admitted to the Third Affiliated Hospital of Beijing University of Chinese Medicine from September 2019 to May 2020 were selected. According to the random number table method, the patients were divided into experimental group (30 cases) and control group (30 cases). The experimental group was given Tongluo Zhitong Gel for external use, and the control group was given low-frequency ultrasonic permeability promoting Tongluo Zhitong Patch for external use. The course of treatment was 14 days. The scores of Western Ontario and McMaster Universities osteoarthritis index (WOMAC), visual analog scale (VAS), Lequesne, and knee circumference of the two groups were recorded before treatment and 7, 14 d after treatment. The efficacy of the two groups was compared, and the occurrence of adverse reactions during treatment was recorded between the two groups. Results The scores of knee VAS, WOMAC, Lequesne, and knee circumference diameter of the two groups at 7, 14 d after treatment were lower than those before treatment, those at 14 d after treatment were lower than those at 7 d after treatment (P＜0.05). The VAS scores of the experimental group at 7, 14 d after treatment were lower than those of the control group at the same time points (P＜0.05). The clinical effect of experimental group was better than that of control group (P＜0.05). During the treatment, one case of mild skin rash appeared in the control group, which was relieved by itself without special treatment. There were no adverse reactions or discomfort symptoms such as skin rash in the experimental group. Conclusion Tongluo Zhitong Gel and low-frequency ultrasonic permeability promoting Tongluo Zhitong Patch are equally effective in improving knee function and swelling degree in patients with KOA, and both have high safety. Tongluo Zhitong Gel is more advantageous in improving the degree of knee pain.
王宝剑 祁印泽 王庆甫 马玉峰▲. 通络止痛凝胶治疗早中期膝骨关节炎的临床研究[J]. 中国医药导报, 2023, 20(6): 95-98.
WANG Baojian QI Yinze WANG Qingfu MA Yufeng▲. Clinical study of Tongluo Zhitong Gel in the treatment of early-middle stage of knee osteoarthritis. 中国医药导报, 2023, 20(6): 95-98.
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