Incidence trend and etiology analysis of upper gastrointestinal bleeding in children
WU Xiaoyu1 FENG Xiaoli1 LI Feng1 CHEN Xiaoyan2
1.Department of Gastroenterology, the Fouth People′s Hospital of Ziyang, Sichuan Province, Ziyang 641300, China;
2.Colleboration Innovation Center of Sichuan for Elderly Care and Health, Chengdu Medical College, Sichuan Province, Chengdu 610500, China
Abstract：Objective To analyze the clinical data of upper gastrointestinal bleeding (UGIB) in children in different years and ages, and to explore the pathogenesis and etiology of UGIB in children in recent years, and to provide reference for clinical intervention, diagnosis, treatment and prognosis. Methods Clinical data of 512 children with symptoms of UGIB in the Fourth People′s Hospital of Ziyang and the First Affiliated Hospital of Chengdu Medical College from January 2013 to December 2017 were retrospectively analyzed, which within male 315 cases (61.5%), female 197 cases (38.5%), the ratio of male to female was 1.6︰1. Children were divided into five periods: infancy, early childhood, preschool, school age and adolescence according to the age. The incidence, change trend, etiology and onset time of UGIB in children were observed and analyzed, and the differences of different etiologies in gender, age and year were compared. Results The incidence of UGIB in each period was significantly different in different years (P < 0.05), except for school age, showed a downward trend over the years. Septicemia, hemophilia, severe pneumonia, purpura and gastritis were the most common causes of UGIB in children. There was no significant difference between male and female in UGIB etiology (P > 0.05). The differences in etiology of children at different stages were statistically significant (P < 0.05). The proportion of septicemia, hemophilia, severe pneumonia and metabolic acidosis gradually decreased with the age of the children, however, the proportion of inflammation and ulcer-like diseases such as purpura, gastritis, duodenal ulcer, coagulation, leukemia, aplastic anemia and other unknown causes gradually increased. Conclusion In recent years, the incidence of UGIB in children has decreased, but the etiology is still complicated, and the focus of prevention and treatment in different ages and different periods should be paid attention to.
2018, Vol. 15 
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