Analysis on the medication rules of traditional Chinese medicine compound prescriptions in the treatment of non-alcoholic fatty liver disease based on the national patent database
1.Graduate School, Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530000, China;
2.Hepatology District One, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530000, China
Abstract：Objective To analyze the medication rules of national traditional Chinese medicine patent compound prescriptions in the treatment of non-alcoholic fatty liver disease (NAFLD) by data mining technology. Methods The traditional Chinese medicine compound prescriptions in the treatment of NAFLD in CNKI patent database and the Patent Search and Analysis System of the State Intellectual Property Office of China from inception to April 2022 were searched. Microsoft Excel software and Traditional Chinese Medicine Inheritance Computing Platform (V3.0) were used for drug frequency statistics, nature, flavour, channel tropism, association rules, and cluster analysis. Results Finally, a total of 93 prescriptions were included, with 241 traditional Chinese medicine. High frequency drugs included Salviae Miltiorrhizae Radix Et Rhizoma, Crataegi Fructus, Alismatis Rhizoma, Bupleuri Radix, Atractylodis Macrocephalae Rhizoma, and so on. The top four efficacies were supplementing deficiency drugs (mainly supplementing qi drugs), diuresis and diffusing dampness drugs, promoting blood circulation for removing blood stasis drugs, and clearing heat drugs. The four nature of drugs were mainly warm, slightly cold, and cold, and the five flavours were bitter, sweet, and pungent, mainly returning to the liver and spleen channels. A total of nine high-frequency couplet medicines, eight drug association rules were discovered, and three types of prescriptions were obtained by cluster analysis. Conclusion The traditional Chinese medicine patent compound prescriptions in the treatment of NAFLD is based on the basic methods of invigorating qi and invigorating spleen, and apply the method of dispersing liver and promoting qi, clearing heat and activating blood, removing dampness and turbidification, and so on.
韦柳婷1 胡振斌2 高松林1 韦玉珍2 张家增1 张臻1. 基于国家专利数据库分析中药复方治疗非酒精性脂肪性肝病的用药规律[J]. 中国医药导报, 2023, 20(5): 137-141.
WEI Liuting1 HU Zhenbin2 GAO Songlin1 WEI Yuzhen2 ZHANG Jiazeng1 ZHANG Zhen1. Analysis on the medication rules of traditional Chinese medicine compound prescriptions in the treatment of non-alcoholic fatty liver disease based on the national patent database. 中国医药导报, 2023, 20(5): 137-141.
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