Discussion on the biological connotation of “theory of thicken intestine” based on intestinal mucus barrier and its application in the diagnosis and treatment of ulcerative colitis
XING Yunqi LI Junxiang ZHANG Wenji HAN Haixiao SUN Zhongmei YUAN Yali MAO Tangyou
Department of Gastroenterology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
Abstract：As a traditional Chinese medicine treatment method, “thicken intestine” appears many times in herbal medical related books and prescriptions, which mainly associated with intestinal diseases, such as bowel, diarrhoea, diuresis, and dysentery. However, due to the vague understanding of “thicken intestine” by most physician, it is generally called enhancing the function of intestine, which hindered the further development of the theory. It is not until the Qing Dynasty that some doctors gradually accurately understood the “thicken intestine” and believed that there is an inherent layer of “lipid membrane” or “ointment” in the intestine, which has the function of “protecting and guiding waste and making it go down”. The thinning of “lipid membrane” or “ointment” caused by damp heat or other reasons is the key pathogenesis of “putrid stool” and “bowel”, which is coupled with the damage of intestinal mucus barrier in modern medicine, the key pathogenesis of ulcerative colitis. Therefore, the corresponding treatment methods based on different pathogenesis of intestinal lipid membrane thinning should be adopted to “eliminate the source of damage, and the thin is thick”, so as to achieve the purpose of “thicken intestine” and finally treat ulcerative colitis, which is similar to the treatment of ulcerative colitis by reconstruction of mucus barrier function in modern medicine. By excavating the classic ancient books of traditional Chinese medicine, this paper traces and extendes the meaning of “theory of thicken intestine”, and deeply discusses its biological connotation from the perspective of intestinal mucus barrier, in order to provide new ideas and methods for the clinical treatment of ulcerative colitis.
邢韵淇 李军祥 张文基 韩海啸 孙中美 袁亚利 毛堂友. 基于肠道黏液屏障探讨“厚肠理论”的生物学内涵及其在溃疡性结肠炎诊治中的应用[J]. 中国医药导报, 2023, 20(5): 128-132.
XING Yunqi LI Junxiang ZHANG Wenji HAN Haixiao SUN Zhongmei YUAN Yali MAO Tangyou. Discussion on the biological connotation of “theory of thicken intestine” based on intestinal mucus barrier and its application in the diagnosis and treatment of ulcerative colitis. 中国医药导报, 2023, 20(5): 128-132.
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