Effect of cognitive behavioral therapy assisted Sertraline on type 2 diabetes mellitus patients combined with depression
ZHANG Hongyan1 ZHANG Yuping2 ZHANG Yanjiao1 ZHENG Jingjing1 BIAN Rui1 WANG Qina3 LI Wenhui4 REN Weidong5
1.The Third Department of Neurology, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
2.Department of Pathophysiology, College of Basic Medicine, Hebei North University, Hebei Province, Zhangjiakou 075000, China;
3.United Front Department of Publicity, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
4.Department of Cardiovascular Medicine, the Second Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075100, China;
5.Department of Endocrinology, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China
Abstract：Objective To investigate the effect of cognitive behavioral therapy assisted Sertraline on type 2 diabetes mellitus patients combined with depression. Methods Sixty patients with type 2 diabetes mellitus patients combined with depression admitted to the First Affiliated Hospital of Hebei North University from January 2019 to December 2020 were selected, and they were divided into control group (30 cases) and experimental group (30 cases) according to the random number table method. The control group took Sertraline Hydrochloride Tablets orally, experimental group was given cognitive behavioral therapy on the basis of control group, and the course of treatment was eight weeks. The clinical efficacy was compared between two groups; the heart rate variability (HRV), fasting insulin (FINS), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR), C-reactive protein (CRP), and total score of Hamilton depression scale (HAMD) were compared between two groups before and after treatment. Results There were four cases dropped out of control group and two cases dropped out of experimental group. The clinical efficacy of experimental group was better than that of control group, and the difference was statistically significant (P＜0.05). Intertemporal population standard deviation of HPV change (SDNN), the mean square root mean square difference of successive sinus R-R intervals of parasympathetic activity (rMSSD), the standard deviation of successive interval difference of parasympathetic accommodation (SDSD), and the high frequency power for parasympathetic modulatory capacity (HF) were higher than those before treatment, low-frequency power for sympathetic activity predominant (LF) and LF/HF were lower than those before treatment, and the differences were statistically significant (P＜0.05); the SDNN, rMSSD, SDSD, and HF of experimental group were higher than those of control group, and LF and LF/HF were lower than those of control group, and the differences were statistically significant (P＜0.05). After treatment, FINS, FBG, HOMA-IR, total score of HAMD, and CRP of two groups were lower than those before treatment, and those of experimental group were lower than those of control group, and the differences were statistically significant (P＜0.05). There was no significant difference in HbA1c between two groups before and after treatment (P＞0.05). Conclusion Cognitive behavioral therapy assisted Sertraline is more effective in the treatment of type 2 diabetes mellitus patients combined with depression, and it has better improvement on HRV, blood glucose, insulin function, and CRP.
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