Expression of long noncoding RNA-AWPPH in the tissues of endometrial cancer patients and its relationship with pathological parameters and prognosis
WANG Bing1 LIN Lin2 GU Te3
1.Out-patient Operating Room, Dalian Women and Children Medical Center (Group), Liaoning Province, Dalian 116021, China;
2.Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Dalian Medical University, Liaoning Province, Dalian 116021, China;
3.Ward Two, Department of Gynaecology, Dalian Women and Children Medical Center (Group), Liaoning Province, Dalian 116021, China
Abstract：Objective To investigate the expression of long noncoding RNA (lncRNA)-AWPPH in the tissues of endometrial cancer (EC) patients and its relationship with pathological parameters and prognosis. Methods A total of 93 EC patients admitted to Dalian Women and Children Medical Center (Group) from January 2017 to December 2018 were selected. LncRNA-AWPPH expression in EC tissues and paracancer tissues was detected by qRT-PCR, and the relationship between the expression and the pathological characteristics of EC was analyzed. According to the mean value of lncRNA-AWPPH expression, patients were divided into high lncRNA-AWPPH expression group (43 cases) and low lncRNA-AWPPH expression group (50 cases). Survival curves were used to analyze the three-year postoperative survival of the two groups. Results LncRNA-AWPPH expression in EC tissues was higher than that in paracancer tissues (P＜0.05). LncRNA-AWPPH expression in EC patients with different Federation Infernational of Gynecology and Obstetrics stages, depth of muscle infiltration, histological stages, lymphatic vascular space infiltration, and lymph node metastasis were statistically significant (P＜0.05). The three-year cumulative survival rate of high lncRNA-AWPPH expression group was lower than that of low lncRNA-AWPPH expression group, and the difference was statistically significant (P＜0.05). Conclusion LncRNA-AWPPH expression is up-regulated in EC tissues, and the survival of patients with high lncRNA-AWPPH expression is poor, which is worthy of further clinical study.
王兵1 林琳2 谷特3. 子宫内膜癌患者组织中长链非编码RNA-AWPPH的表达及其与病理参数和预后的关系[J]. 中国医药导报, 2023, 20(2): 93-96.
WANG Bing1 LIN Lin2 GU Te3. Expression of long noncoding RNA-AWPPH in the tissues of endometrial cancer patients and its relationship with pathological parameters and prognosis. 中国医药导报, 2023, 20(2): 93-96.
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