Analysis of influencing factors in patients with ischemic leukodystrophy
YE Xin1 LIU Shihua2 ZHANG Chao2 ZHONG Ping2▲
1.Department of General Practice, Suzhou Hospital of Anhui Medical University, Anhui Province, Suzhou 234000, China;
2.Department of Neurology, Suzhou Hospital of Anhui Medical University, Anhui Province, Suzhou 234000, China
Abstract：Objective To investigate the influencing factors of disease progression in patients with white matter ischemic lesions (WMIL). Methods Clinical data of 215 patients with WMIL admitted to Suzhou Hospital of Anhui Medical University from June 2017 to September 2021 were collected. The degree of leukodystrophy was assessed according to the Fazekas scale; the control group (100 cases) had normal brain MRI. The serum concentration of asymmetric dimethylarginine (ADMA) was determined by enzyme-related immunosorbent assay. The clinical data and ADMA concentration of the two groups were compared to analyze the influencing factors of ischemic white matter lesions and the relationship between serum ADMA and the degree of white matter lesions. Results The proportion of hypertension and type 2 diabetes in WMIL group was higher than that in control group, while the serum ADMA concentration in light, medium and heavy WMIL group were higher than that in control group, and the differences were statistically significant (P＜0.05). Spearman rank correlation analysis showed that serum ADMA concentration in WMIL group was positively correlated with Fazekas score (r=0.850, P＜0.01). Multivariate logistic analysis showed that hypertension, diabetes history, and elevated serum ADMA were independent risk factors for WMIL progression (OR＞1, P＜0.05). Conclusion High concentration of ADMA is an independent factor affecting the progression of WMIL, and the higher the concentration, the more severe the degree of leukoencephalopathy.
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