Abstract：Objective To analyze the correlation between the levels of vascular endothelial growth factor (VEGF), homocysteine (Hcy), and macular edema degree of retinal vein occlusion. Methods Eighty patients with retinal vein occlusion and macular edema admitted to Zhangjiakou First Hospital of Hebei Province (hereinafter referred to as “our hospital”) from April 2021 to January 2022 were included in the study group, another 80 healthy people who underwent physical examination in our hospital during the same period were included in the health group, and another 80 patients with simple retinal vein occlusion admitted to our hospital during the same period were included in the control group. The serum levels of VEGF and Hcy were compared among the three groups, and the correlation between them and the macular edema degree of retinal vein occlusion was analyzed. Results The levels of serum VEGF and Hcy in study group and control group were higher than those in healthy group, and the study group was higher than the control group, and the differences were statistically significant (P＜0.05). In the study group, 46 patients were mild macular edema of retinal vein occlusion, 24 patients were moderate, and 10 patients were severe. The serum levels of VEGF and Hcy in moderate and severe patients were higher than those in mild patients, and those in severe patients were higher than those in moderate group, the differences were statistically significant (P＜0.05). Correlation analysis results showed that there was no correlation between serum VEGF level and macular edema degree in patients with retinal vein occlusion (P＞0.05), but serum Hcy level was positively correlated with edema degree (rs＞0, P＜0.05). Conclusion Serum levels of VEGF and Hcy in patients with retinal vein occlusion and macular edema are higher than those in patients with simple retinal vein occlusion and healthy people. Clearing Hcy level may increase the severity of macular edema with retinal vein occlusion, which requires clinical observation.
何敬 马楠 霍红 范红芳 侯丽萍 张洁 王淑珍▲. 血清血管内皮生长因子、同型半胱氨酸与视网膜静脉阻塞黄斑水肿程度的相关性分析[J]. 中国医药导报, 2023, 20(1): 107-110.
HE Jing MA Nan HUO Hong FAN Hongfang HOU Liping ZHANG Jie WANG Shuzhen▲. Correlation analysis of serum vascular endothelial growth factor, homocysteine, and macular edema degree of retinal vein occlusion. 中国医药导报, 2023, 20(1): 107-110.
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