The mechanism and research progress of pyroptosis in arthritis
YANG Qinglin1 XIE Ben1 YANG Dubin1 WANG Yikun1 QIN Qingqing1 WANG Yongping2
1.The First School of Clinical Medical, Lanzhou University, Gansu Province, Lanzhou 730000, China;
2.Department of Orthopedics, the First Hospital of Lanzhou University, Gansu Province, Lanzhou 730000, China
Abstract：Pyrodeath is a particular type of programmed cell death. It is regulated by the pyroporin family and is characterized by membrane perforation, cell swelling, and the release of a large number of pro-inflammatory factors. Relevant studies have shown that the key components of pyroptosis are closely related to the occurrence and development of rheumatoid arthritis, osteoarthritis, and gouty arthritis. This article mainly reviews the molecular mechanism of pyroptosis activation and its mechanism and progress in arthritis, aiming to provide reference for the related research of pyroptosis and arthritis.
阳庆林1 谢犇1 杨杜斌1 王一坤1 秦庆庆1 王勇平2. 细胞焦亡在关节炎中的作用机制及研究进展[J]. 中国医药导报, 2023, 20(1): 49-52,60.
YANG Qinglin1 XIE Ben1 YANG Dubin1 WANG Yikun1 QIN Qingqing1 WANG Yongping2. The mechanism and research progress of pyroptosis in arthritis. 中国医药导报, 2023, 20(1): 49-52,60.
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