Study on drug laws of Beiji Qianjin Yao Fang and Qianjin Yi Fang in the treatment of renal edema based on data mining
LI Xiyao1 GAO Hongjie2 SUN Luying1 BAO Wujisiguleng1 ZHANG Mingzhu1 WEI Shuguang1
1.Department of Nephrology and Endocrinology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;
2.Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
Abstract：Objective To use the data mining technology to explore and summarize the drug laws of the treatment of renal edema in Beiji Qianjin Yao Fang and Qianjin Yi Fang (hereinafter referred to as Qianjin Fang). Methods The prescriptions for treating renal edema in Qianjin Fang were selected to establish a standard medical record database, and the cloud platform of ancient and modern medical records was used to make statistics on drug frequency, drug properties, drug flavor, channel tropism, drug association rules, and cluster analysis. Results A total of 67 formulas for the treatment of renal edema from Qian Jin Fang were included in this study, involving 67 prescriptions, among which 44 were Beiji Qianjin Yao Fang and 23 were Qianjin Yi Fang. A total of 144 traditional Chinese medicine were involved, and the top three drugs with high frequency were Atractylodis Macrocephalae Rhizoma, Poria, and Cinnamomi Ramulus. The drug properties were more warm, the drug flavors were more sweet, pungent, and bitter, more return to the lung, spleen, kidney channel. The drug efficacy was more inducing diuresis for removing edema, invigorating spleen, diuresis and diffusing dampness, dispelling pathogenic wind and relieving pain, eliminating dampness and diuresis, and so on. In the association rules of the two drug patterns, the confidence of Stephaniae Tetrandrae Radix→Atractylodis Macrocephalae Rhizoma was the highest. Drugs used more than 20 times could be grouped into four groups by cluster analysis. Conclusion Through data mining, the differentiation and treatment ideas of renal edema in Qianjin Fang are shown, that is, the idea of taking deficiency and excess as the key line, sanjiao as the differentiation method and elimination as the method is formed, which provided reference for the clinical practice of traditional Chinese medicine treatment of renal edema.
李希尧1 高宏杰2 孙鲁英1 包乌吉斯古冷1 张明珠1 魏曙光1. 《备急千金要方》和《千金翼方》治疗肾系水肿用药规律挖掘研究[J]. 中国医药导报, 2022, 19(36): 135-139.
LI Xiyao1 GAO Hongjie2 SUN Luying1 BAO Wujisiguleng1 ZHANG Mingzhu1 WEI Shuguang1. Study on drug laws of Beiji Qianjin Yao Fang and Qianjin Yi Fang in the treatment of renal edema based on data mining. 中国医药导报, 2022, 19(36): 135-139.
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