Clinical effect of GnRHa combined with LNG-IUS regimen in the treatment of adenomyosis
YU Lingyun1 HUANG Xiaoqin2 SHEN Hengchun1▲
1.Department of Obstetrics and Gynecology, Affiliated Hospital of Southwest Medical University, Sichuan Province, Luzhou 646000, China;
2.Department of Obstetrics and Gynecology, Neijiang First People’s Hospital, Sichuan Province, Neijiang 641000, China
Abstract：Objective To investigate the clinical effect of gonadotropin-releasing hormone agonist (GnRHa) combined with levonorgestrel intrauterine release system (LNG-IUS) in the treatment of adenomyosis. Methods A total of 90 patients with adenomyosis admitted to Neijiang First People’s Hospital of Sichuan Province from May 2018 to January 2021 were selected. They were divided into two groups by random number table method, with 45 cases in each group. The experimental group was given GnRHa and LNG-IUS combined treatment, and the control group was given single GnRHa treatment. Visual analogue scale (VAS), menstrual volume score, uterine volume, endometrial thickness, and carbohydrate antigen-125 (CA125) level were compared between two groups before treatment, six months after treatment, and one year after treatment, and the occurrence of adverse reactions was observed. Results Six months and one year after treatment, VAS score, uterine volume, endometrial thickness, menstrual volume score, and CA125 between two groups were less than those before treatment, and the differences were statistically significant (P＜0.05). One year after treatment, VAS score of the experimental group was lower than that six months after treatment; VAS score, endometrial thickness, and CA125 of control group were lower than those six months after treatment, and the differences were statistically significant (P＜0.05). Six months after treatment, VAS score, uterine volume, endometrial thickness, menstrual volume score, and CA125 of experimental group were lower than those of control group, and the differences were statistically significant (P＜0.05). One year after treatment, VAS score, uterine volume, menstrual volume score, and CA125 of experimental group were lower than those of control group, and the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P＞0.05). Conclusion The combination of GnRHa and LNG-IUS in the treatment of adenomyosis has a better curative effect and a superior application prospect.
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