Research progress on the protective effect of Dapagliflozin on kidney and cardiovascular
WANG Wenjing ZHENG Wenfei LI Shengnan LIU Qian #br#
Department of Endocrinology, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250001, China
Abstract：Dapagliflozin, sodium-glucose cotransporter 2 inhibitor, a new type of hypoglycemic agent. Dapagliflozin effectively inhibits the renal tubule SGLT2 receptor, reduces the renal tubule glucose reabsorption, and promotes the glucose excretion from urine, and reduces blood glucose levels in a non-insulin-dependent manner. In addition to lowering blood glucose, Dapagliflozin also has osmotic diuretic, weight loss, antihypertensive, lipid lowering, urate lowering, and other effects, and plays a protective effect of heart and kidney through anti-fibrosis, anti-inflammatory, antioxidant stress, improving mitochondrial function, regulating autophagy, and restoring tube-ball balance and so on. This article summarizes the protective effect and possible mechanisms of Dapagliflozin on kidney and cardiovascular, in order to provide reference for the clinical application of the drug.
王文静 郑文斐 李胜男 刘乾. 达格列净对肾脏和心血管保护效应研究进展[J]. 中国医药导报, 2022, 19(36): 62-65.
WANG Wenjing ZHENG Wenfei LI Shengnan LIU Qian . Research progress on the protective effect of Dapagliflozin on kidney and cardiovascular. 中国医药导报, 2022, 19(36): 62-65.
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