CiteSpace-based visualization of the current status of the application of Sinomenine in Chinese medicine research
ZHANG Zixuan1 AN Yi1 ZHANG Xinwen1 ZHAO Xin1 ZHANG Xieyu1 ZHAO Jiahe2 CAO Wei3
1.Guang’anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing 100053, China;
2.School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
3.Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China
Abstract：Objective To analyze the current status and future development trend of Chinese medicine related research on Sinomenine in the past 20 years at home and abroad by scientific knowledge mapping methods. Methods The research literatures related to Sinomenine from January 2001 to April 2022 included in China Knowledge Network and Web of Science databases were searched, and the authors, countries, institutions, and keywords were visualized analyzed by CiteSpace software. Results A total of 973 Chinese literatures and 264 English literatures were obtained. The number of publications on Sinomenine research had shown a fluctuating upward trend in the last 20 years. Zhou Liling and Liu Liang were the authors with the highest number of publications in English and Chinese, respectively. The publishing institutions were concentrated in China, mainly in Guangzhou University of Chinese Medicine, but there was a lack of cooperation between teams and institutions. Keywords analysis showed that Sinomenine, proliferation, apoptosis, rat, and cyanophylline were the hotspots of cyanophylline research in Chinese, cell expression, apoptosis, activation, metabolism, inhibition, rheumatoid arthritis, mouse, and proliferation were the hotspots of research in English, and domestic and foreign research trends focused on apoptosis and cell proliferation. Conclusion At present, the field of Cyanophylline is in the rising stage of development, and the research hotspots and trends are apoptosis and cell proliferation, but there is little cooperation among team institutions, and the communication and cooperation should be increased, which is conducive to promoting the long-term development of cyanophylline.
张子旋1 安逸1 张馨文1 赵鑫1 张解玉1 赵珈禾2 曹炜3. 基于CiteSpace对青藤碱在中医药研究应用现状的可视化分析[J]. 中国医药导报, 2022, 19(36): 29-35.
ZHANG Zixuan1 AN Yi1 ZHANG Xinwen1 ZHAO Xin1 ZHANG Xieyu1 ZHAO Jiahe2 CAO Wei3. CiteSpace-based visualization of the current status of the application of Sinomenine in Chinese medicine research. 中国医药导报, 2022, 19(36): 29-35.
[1] 黄红，胡明月，徐丽，等.青藤碱免疫抑制作用机制的研究进展[J].中草药，2022，53（1）：261-269.
[2] 李时珍.本草纲目[M].北京：人民卫生出版社，2005：1340.
[3] Jiang W，Fan W，Gao T，et al. Analgesic Mechanism of Sinomenine against Chronic Pain [J]. Pain Res Manag，2020，2020：1876862.
[4] Tang J，Raza A，Chen J，et al. A Systematic Review on the Sinomenine Derivatives [J]. Mini Rev Med Chem，2018，18（11）：906-917.
[5] Zhang MW，Wang XH，Shi J，et al. Sinomenine in Cardio- Cerebrovascular Diseases：Potential Therapeutic Effects and Pharmacological Evidences [J]. Front Cardiovasc Med，2021， 8：749113.
[6] Lin SS，Liu CX，Zhang JH，et al. Efficacy and Safety of Sinomenine Preparation for Ankylosing Spondylitis：A Systematic Review and Meta-Analysis of Clinical Randomized Controlled Trials [J]. Evid Based Complement Alternat Med，2020，2020：4593412.
[7] 龙海燕，刘雁鸣，陈得雨，等.正清风痛宁注射液的沿革及展望[J].中南药学，2012，10（4）：303-306.
[8] Ramakreshnan L，Aghamohammadi N，Fong CS，et al. A comprehensive bibliometrics of ‘walkability’ research landscape：visualization of the scientific progress and future prospects [J]. Environ Sci Pollut Res Int，2021，28（2）：1357- 1369.
[9] Dang Q，Luo Z，Ouyang C，et al. First Systematic Review on Health Communication Using the CiteSpace Software in China：Exploring Its Research Hotspots and Frontiers [J]. Int J Environ Res Public Health，2021，18（24）：13008.
[10] 邵继征，周莉玲，周郁斌.青藤碱在家兔体内药动-药效学结合研究[J].中药新药与临床药理，2013，24（6）：597-601.
[11] 张先洲，范金玲，潘细贵.不同剂型青藤碱的体外皮肤渗透性[J].中国医院药学杂志，2011，31（11）：901-903.
[12] 朱晨，林汝堃，区炳雄，等.三种中药活性成分对吗啡依赖斑马鱼脑中dre-miR-723-5p表达的影响[J].中国药理学通报，2021，37（11）：1542-1547.
[13] Bai S，Wen W，Hou X，et al. Inhibitory effect of sinomenine on lung cancer cells via negative regulation of α7 nicotinic acetylcholine receptor [J]. J Leukoc Biol，2021，109（4）：843-852.
[14] Yi L，Ke J，Liu J，et al. Sinomenine increases adenosine A2A receptor and inhibits NF-κB to inhibit arthritis in adjuvant-induced-arthritis rats and fibroblast-like synoviocytes through α7nAChR [J]. J Leukoc Biol，2021，110（6）：1113-1120.
[15] 鄢森，滕健，孙彤彤，等.电致孔方式对盐酸青藤碱经皮渗透的促进作用[J].中国实验方剂学杂志，2021，27（17）：146-151.
[16] 任明军，胡云飞，朱永波，等.基于色谱指纹图谱和含量测定相结合的青风藤质量控制方法研究[J].中草药，2022， 53（5）：1338-1344.
[17] 王海燕，王钊华，马波.青藤碱联合顺铂对顺铂耐药Hela细胞株增殖凋亡的作用[J].武警医学，2022，33（2）：158- 162.
[18] 李晓梅.盐酸青藤碱抑制乳腺癌干细胞干性及其机制的研究[D].遵义：遵义医科大学，2021.
[19] 吴大春，谌雁冰.基于ERK/MAPK信号通路探讨青藤碱对SW480结肠癌细胞活性抑制作用的研究[J].西部中医药，2021，34（6）：13-18.
[20] 李吉业，辛国松，于淼，等.基于肿瘤细胞膜受体干预的青藤碱抗肝癌作用机制研究[J].中药材，2021，44（3）：667-673.
[21] Kour G，Haq SA，Bajaj BK，et al. Phytochemical add-on therapy to DMARDs therapy in rheumatoid arthritis：In vitro and in vivo bases，clinical evidence and future trends [J]. Pharmacol Res，2021，169：105618.
[22] Liu W，Qian X，Ji W，et al. Effects and safety of Sinomenine in treatment of rheumatoid arthritis contrast to methotrexate：a systematic review and Meta-analysis [J]. J Tradit Chin Med，2016，36（5）：564-577.
[23] Huang RY，Pan HD，Wu JQ，et al. Comparison of combination therapy with methotrexate and sinomenine or leflunomide for active rheumatoid arthritis：A randomized controlled clinical trial [J]. Phytomedicine，2019，57：403-410.
[24] Jia E，Hu S，Geng H，et al. Zhengqing fengtongning sustained-release tablets prevents gout flares in the process of ULT： A randomized，positive control，double-blind，double-simulation，multicenter trial [J]. Medicine （Baltimore），2022，101（18）：e29199.
[25] Huang Z，Mao X，Chen J，et al. The Efficacy and Safety of Zhengqing Fengtongning for Knee Osteoarthritis：A Systematic Review and Meta-Analysis of Randomized Clinical Trials [J]. Evid Based Complement Alternat Med，2022， 2022：2768444.
[26] Huang Z，Mao X，Chen J，et al. Sinomenine hydrochloride injection for knee osteoarthritis：A protocol for systematic review and meta-analysis [J]. Medicine （Baltimore），2022， 101（2）：e28503.
[27] Bi F，Zhang Y，Liu W，et al. Sinomenine activation of Nrf2 signaling prevents inflammation and cerebral injury in a mouse model of ischemic stroke [J]. Exp Ther Med，2021， 21（6）：647.
[28] Zhang MW，Wang XH，Shi J，et al. Sinomenine in Cardio-Cerebrovascular Diseases：Potential Therapeutic Effects and Pharmacological Evidences [J]. Front Cardiovasc Med，2021，8：749113.
[29] Xu H，Dong J，Hou J，et al. Sinomenine Inhibits the Progression of Bladder Cancer Cells by Downregulating LncRNA-HEIH Expression [J]. Evid Based Complement Alternat Med，2021，2021：4699529.
[30] Bai S，Wen W，Hou X，et al. Inhibitory effect of sinomenine on lung cancer cells via negative regulation of α7 nicotinic acetylcholine receptor [J]. J Leukoc Biol，2021，109（4）：843-852.
[31] Duan D，Wang Y，Pan D，et al. Rheumatoid arthritis drug sinomenine induces apoptosis of cervical tumor cells by targeting thioredoxin reductase in vitro and in vivo [J]. Bioorg Chem，2022，122：105711.
[32] Zheng X，Li W，Xu H，et al. Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/ mTOR pathway [J]. Acta Pharm Sin B，2021，11（11）：3465- 3480.
[33] Zhu M，Wang H，Chen J，et al. Sinomenine improve diabetic nephropathy by inhibiting fibrosis and regulating the JAK2/STAT3/SOCS1 pathway in streptozotocin-induced diabetic rats [J]. Life Sci，2021，265：118855.
[34] Yuan M，Zhao B，Jia H，et al. Sinomenine ameliorates cardiac hypertrophy by activating Nrf2/ARE signaling pathway [J]. Bioengineered，2021，12（2）：12778-12788.
[35] Yang Z，Liu Y，Yuan F，et al. Sinomenine inhibits microglia activation and attenuates brain injury in intracerebral hemorrhage [J]. Mol Immuno，2014，60（2）：109-114.
[36] Wang X，Liu Y，Zhang H，et al. Sinomenine alleviates dorsal root ganglia inflammation to inhibit neuropathic pain via the p38 MAPK/CREB signalling pathway [J]. Eur J Pharmacol，2021，897：173945.
[37] 李嘉，付婷婷，张光峰，等.青藤碱通过miR-23b-3p/ FGF9诱导人类风湿关节炎成纤维细胞样滑膜细胞凋亡[J].中国病理生理杂志，2020，36（9）：1653-1660.
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