Abstract：Objective To explore the clinical effect of Zhixiong Capsules in treating convalescent period of cerebral infarction with syndrone of static blood blocking collaterals. Methods A total of 86 patients with convalescent period of cerebral infarction admitted to Fuxin Mine General Hospital of Liaoning Health Industry Group from January 2019 to January 2022 were selected and divided into control group and combination group by random number table method, with 43 cases in each group. On the basis of conventional treatment, the control group was given Butylphthalide Capsules, and the combination group was given Zhixiong Capsules combined with Butylphthalide Capsules. After 14 days of treatment, the clinical efficacy of two groups was compared, and the simplified Fugl-Meyer scale (FMA) score, modified Barthel index (MBI), National Institutes of Health stroke scale (NIHSS) score, plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, and serum vascular endothelial growth factor (VEGF), neuron-specific enolase (NSE), cell matrix-derived factor-1 (SDF-1) levels before and after treatment were compared between the two groups. The occurrence of adverse reactions during treatment was recorded in both groups. Results The overall curative effect of the combination group was better than that of the control group (P＜0.05). After treatment, NIHSS score, plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, and serum NSE level were all lower than those before the treatment, while FMA score, MBI, and serum VEGF and SDF-1 levels were all higher than those before the treatment, NIHSS score, plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, and serum NSE level in combination group were lower than those in control group, while FMA score, MBI, and serum VEGF and SDF-1 levels were higher than those in control group, the differences were statistically significant (P＜0.05). During the treatment period, no serious adverse reactions occurred in both groups. Conclusion In the convalescent period of cerebral infarction, the treatment effect of Zhixiong Capsules combined with Butylphthalide Capsules is significant, which is conducive to improving the hemodynamics and quality of life of patients, and is worthy of clinical promotion.
衣丽华 郑丽莎 王佳 刘迪. 蛭芎胶囊治疗瘀血阻络型脑梗死恢复期的临床效果[J]. 中国医药导报, 2022, 19(35): 74-77.
YI Lihua ZHENG Lisha WANG Jia LIU Di. Clinical effect of Zhixiong Capsules in treating convalescent period of cerebral infarction with syndrome of static blood blocking collaterals. 中国医药导报, 2022, 19(35): 74-77.
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