Bayesian network meta-analysis of the efficacy of external treatment of traditional Chinese medicine in the treatment of post-stroke constipation
HE Shuhong1 ZHU Luwen2 LI Hongyu3 TANG Qiang3▲
1.Graduate School, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
2.the Fourth Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150070, China;
3.the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150001, China
Abstract：Objective To evaluate the effect of external treatment of traditional Chinese medicine in the treatment of post-stroke constipation. Methods Computer search was conducted on China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, VIP Data, Chinese Biomedical Literature Database, The Cochrane Library, PubMed, and Embase from the inception to August, 2021. Randomized controlled literatures on the efficacy of external treatment of traditional Chinese medicine in the treatment of post-stroke constipation patients were included. The Cochrane collaborative network bias risk assessment tool was used for quality assessment, and R software gemtc package and JAGS software were used for Bayesian network meta-analysis. Results Among the 1 605 literatures retrieved, 27 randomized controlled trial studies were included. The results of network meta-analysis showed that compared with conventional treatment, moxibustion + conventional treatment (OR=3.82, 95%CI [1.56, 10.13], P＜0.05), electroacupuncture + conventional treatment (OR=2.77, 95%CI [1.45, 5.79], P＜0.05), auricular point sticking + conventional treatment (OR=4.72, 95%CI [2.35, 10.14], P＜0.05), common acupuncture + conventional treatment (OR=4.35, 95%CI [2.68, 7.21], P＜0.05), acupoint massage + conventional treatment (OR=4.48, 95%CI [1.25, 16.10], P＜0.05), acupoint application + conventional treatment (OR=4.82, 95%CI [1.31, 23.26], P＜0.05) could significantly improve the overall patient response rate; there was no statistical difference between the external treatment of traditional Chinese medicine methods (P＞0.05). The results of network meta sorting showed that auricular point sticking + conventional treatment (0.685) > acupoint application + conventional treatment (0.669) > common acupuncture + conventional treatment (0.633) > acupoint massage + conventional treatment (0.621) > moxibustion + conventional treatment (0.538) > electroacupuncture + conventional treatment (0.350) > conventional treatment (0.004). Conclusion Compared with conventional treatment, external treatment of traditional Chinese medicine can effectively improve post-stroke constipation. The top three curative effects are auricular point sticking, acupoint application, and ordinary acupuncture. Due to the limited sample size of the literature, large samples and high-quality literature are still needed to be verified in the future.
赫书宏1 朱路文2 李宏玉3 唐强3▲. 中医外治法治疗中风后便秘效果的贝叶斯网状meta分析[J]. 中国医药导报, 2022, 19(34): 120-125.
HE Shuhong1 ZHU Luwen2 LI Hongyu3 TANG Qiang3▲. Bayesian network meta-analysis of the efficacy of external treatment of traditional Chinese medicine in the treatment of post-stroke constipation. 中国医药导报, 2022, 19(34): 120-125.
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