自拟消胀清宿汤结合针刺治疗气机阻滞型习惯性便秘的临床效果

doi:10.20047/j.issn1673-7210.2022.33.29

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摘要目的观察自拟消胀清宿汤结合针刺治疗气机阻滞型习惯性便秘的效果。方法选取2020年11月至2021年9月河北省三河市医院就诊的120例习惯性便秘患者作为研究对象，采用随机数字表法将其分为治疗组、对照组1和对照组2，每组各40例。对照组1采用自拟消胀清宿汤结合比沙可啶肠溶片的方法进行治疗，对照组2采用针刺结合比沙可啶肠溶片的方法进行治疗，治疗组在口服比沙可啶肠溶片的基础上，采用自拟消胀清宿汤结合针刺的方法进行治疗，治疗1周。在治疗前、治疗1周后与治疗后3个月观察患者血管活性肠肽（VIP）、胃动素（MTL）、血清5-羟色胺（5-HT）水平，并在治疗后观察中医病证诊断疗效变化。结果整体分析发现：治疗组与对照组1，治疗组与对照组2的VIP水平组间、时间点及交互作用比较，差异均有统计学意义（P ＜ 0.05）。组内比较：与治疗前比较，治疗组、对照组1及对照组2的VIP水平在治疗1周后降低，治疗组在治疗后3个月的VIP水平降低，差异有统计学意义（P ＜ 0.05）。组间比较：治疗组在治疗1周后、治疗后3个月的VIP水平均明显低于对照组1、对照组2，差异有统计学意义（P ＜ 0.05）。整体分析发现：治疗组与对照组1，治疗组与对照组2的MTL水平组间、时间点及交互作用比较，差异均有统计学意义（P ＜ 0.05）。组内比较：与治疗前比较，治疗组、对照组1及对照组2的MTL水平在治疗后1周后、治疗后3个月均升高，差异有统计学意义（P ＜ 0.05）。组间比较：治疗组在治疗后3个月的MTL水平均要明显高于对照组1、对照组2，差异有统计学意义（P ＜ 0.05）。整体分析发现：治疗组与对照组1，治疗组与对照组2的5-HT水平组间、时间点及交互作用比较，差异均有统计学意义（P ＜ 0.05）。组内比较：与治疗前比较，治疗组、对照组1及对照组2的5-HT水平在治疗1周后、治疗后3个月均升高，差异有统计学意义（P ＜ 0.05）。组间比较：治疗组在治疗1周后、治疗后3个月的5-HT水平均明显高于对照组1、对照组2，差异有统计学意义（P ＜ 0.05）。治疗组治愈情况优于对照组1及对照组2，差异有统计学意义（P ＜ 0.05）。结论自拟消胀清宿汤结合针刺治疗气机阻滞型习惯性便秘效果较为明显，为气机阻滞型习惯性便秘的治疗方案提供了新的选择。

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	张建军1 刘海永2▲ 王娟3 刘艳东4 刘雅丽5 白荟芳5 凌书娟6 王凤林7

关键词 ：自拟消胀清宿汤, 针刺, 联合治疗, 气机阻滞型, 习惯性便秘

Abstract：Objective To observe the effect of self-designed Xiaozhang Qingsu Decoction combined with acupuncture in the treatment of habitual constipation of qi movement block type. Methods A total of 120 patients with habitual constipation who visited Sanhe Hospital of Hebei Province from November 2020 to September 2021 were selected as the research objects. They were divided into treatment group, control group 1 and control group 2 by random number table method, with 40 cases in each group. The control group 1 was treated with self-designed Xiaozhang Qingsu Decoction combined with Bisacodyl Enteric-coated Tablets, the control group 2 was treated with acupuncture combined with Bisacodyl Enteric-coated Tablets, and the treatment group was treated with self-designed Xiaozhang Qingsu Decoction combined with acupuncture on the basis of oral Bisacodyl Enteric-coated Tablets. Treatment for one weeks. The levels of vasoactive intestinal peptide (VIP), motilin (MTL), and serum 5-hydroxytryptamine (5-HT) were observed before treatment, one week after treatment and three months after treatment, and the therapeutic effect of traditional Chinese medicine syndrome diagnosis was observed after treatment. Results The overall analysis showed that there were statistically significant differences in VIP levels between the treatment group and the control group 1, between the treatment group and the control group 2, between the groups, time points, and interaction （P ＜ 0.05）. Intra-group comparison: compared with before treatment, the VIP level of treatment group, control group 1 and control group 2 was decreased one week after treatment, and the VIP level of treatment group was decreased three months after treatment, and the differences were statistically significant (P ＜ 0.05). Comparison between groups: the VIP level of the treatment group was significantly lower than that of control group 1 and control group 2 at one week and three months after treatment, and the differences were statistically significant (P ＜ 0.05). The overall analysis showed that there were statistically significant differences in MTL levels between the treatment group and the control group 1, between the treatment group and the control group 2, between the groups, time points, and interaction (P ＜ 0.05). Intra-group comparison: compared with before treatment, MTL levels in treatment group, control group 1 and control group 2 were increased at one week and three months after treatment, and the differences were statistically significant (P ＜ 0.05). Comparison between groups: after three months of treatment, the MTL level of the treatment group was significantly higher than that of control group 1 and control group 2, and the differences were statistically significant (P ＜ 0.05). The overall analysis showed that there were statistically significant differences in 5-HT levels between the treatment group and the control group 1, between the treatment group and the control group 2, between the groups, time points, and interaction (P ＜ 0.05). Intra-group comparison: compared with before treatment, the levels of 5-HT in treatment group, control group 1 and control group 2 were increased one week and three months after treatment, and the differences were statistically significant (P ＜ 0.05). Comparison between groups: the level of 5-HT in the treatment group was significantly higher than those in the control group 1 and 2 at one week and three months after treatment, and the differences were statistically significant (P ＜ 0.05). The cure of treatment group was better than that of control group 1 and control group 2, and the differences were statistically significant (P ＜ 0.05). Conclusion The self-designed Xiaozhang Qingsu Decoction combined with acupuncture has obvious effect on the treatment of habitual constipation of qi movement block type, which provides a new choice for the treatment of habitual constipation of qi movement block type.

Key words： Self-designed Xiaozhang Qingsu Decoction Acupuncture Combination therapy Qi movement block type Habitual constipation

基金资助:河北省中医药管理局科研计划项目（2021372）。

通讯作者: ▲通讯作者

引用本文:

张建军1 刘海永2▲ 王娟3 刘艳东4 刘雅丽5 白荟芳5 凌书娟6 王凤林7. 自拟消胀清宿汤结合针刺治疗气机阻滞型习惯性便秘的临床效果[J]. 中国医药导报, 2022, 19(33): 128-133.
ZHANG Jianjun1 LIU Haiyong2▲ WANG Juan3 LIU Yandong4 LIU Yali5 BAI Huifang5 LING Shujuan6 WANG Fenglin7. Clinical effect of self-designed Xiaozhang Qingsu Decoction combined with acupuncture in the treatment of habitual constipation of qi movement block type. 中国医药导报, 2022, 19(33): 128-133.

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https://www.yiyaodaobao.com.cn/CN/10.20047/j.issn1673-7210.2022.33.29 或 https://www.yiyaodaobao.com.cn/CN/Y2022/V19/I33/128

[1] 吕冠华.从脾肾论治习惯性便秘的思路与方法[J].辽宁中医杂志，2021，48（7）：57-59.
[2] 相翠玉，刘洁，张永洲，等.加味四磨汤治疗成人功能性便秘及对肠道神经递质的影响[J].中国实验方剂学杂志，2019，25（2）：150-155.
[3] 刘宁宁，李合国.李合国运用塞因塞用法治疗习惯性便秘经验[J].中国民间医药，2020，28（3）：14-16.
[4] 李家诚，刘华.基于真实世界数据分析的中医治疗便秘用药规律研究[J].上海中医药杂志，2021，55（3）：27-30， 64.
[5] 杨云生，彭丽华.功能性胃肠病罗马诊断标准与研究现状[J].解放军医学院学报，2013，34（6）：541-543.
[6] 中华中医药学会脾胃病分会.便秘中医诊疗专家共识意见（2017）[J].中医杂志，2017，58（15）：1345-1350.
[7] 洪燕秋，张书信，肖秋平，等.肠润方对功能性便秘患者肠道菌群调节作用的临床研究[J].河北中医药学报，2021， 36（4）：13-17.
[8] 中华中医药学会脾胃病分会.便秘中医诊疗专家共识意见（2017）[J].中医杂志，2017，58（15）：1345-1349.
[9] 梁彪，施展，王建东，等.基于中医传承辅助平台的中医药治疗功能性便秘用药规律研究[J].世界中西医药结合杂志，2021，16（5）：829-933，838.
[10] 王旭峰，胥冬梅.黄芪白术通便汤治疗老年功能性便秘的临床观察[J].中国中医药科技，2018，25（5）：737-738.
[11] 张杨蓉，陈一斌.中医药治疗便秘型肠易激综合征研究进展[J].中国医药导刊，2021，23（8）：565-568.
[12] 乔明月，禄保平，蓉金霞.老年性便秘的中医药治疗现状[J].中医学报，2020，35（4）：802-806.
[13] Xue Z，Wu C，Wei J，et al. An orally administered magnoloside A ameliorates functional dyspepsia by modulating brain-gut peptides and gut microbiota [J]. Life Sci，2019， 233（15）：116749.
[14] 郭玲，陈晓芳，田春燕，等.基于子午流注理论穴位贴敷联合中医定向透药治疗脊柱骨折术后便秘的疗效分析[J].实用临床医药杂志，2021，25（12）：83-85，89.
[15] 李敏，劳慧敏，陈鲁，等.中医药治疗小儿功能性便秘用药规律分析[J].中医药导报，2020，26（2）：106-110.
[16] 王伟松，袁恒佑，刘建和，等.全国名中医王行宽多脏调燮治疗功能性便秘的经验[J].湖南中医药大学学报，2021， 41（6）：893-896.
[17] 魏小丽，王宇航，李成，等.针刺天枢穴联合莫沙必利治疗习惯性便秘及对血清VIP、MTL、5-HT的影响[J].中华中医药学刊，2021，39（7）：95-98.
[18] 王梁凤，张小飞，李慧婷，等.基于数据挖掘的芳香类中药治疗便秘高频次使用药对“陈皮-木香”网络药理学研究[J].中国中药杂志，2020，45（9）：2103-2114.
[19] 刘经州，高英杰，刘宝林，等.针刺联合生物反馈疗法对产后便秘疗效观察[J].河北医学，2019，25（3）：688-690.
[20] 张春霞.莫沙必利治疗糖尿病胃肠功能紊乱的临床疗效观察[J].临床合理用药杂志，2019，12（13）：56-57.
[21] 刘爱国，吴秀玲，徐静红，等.电针足三里治疗帕金森患者便秘48例临床观察[J].中医药导报，2018，24（3）：101- 103，108.
[22] 陈萌，于永铎，隋楠，等.基于子午流注理论探讨化瘀通便汤治疗慢传输型便秘的临床研究[J].辽宁中医杂志，2020，47（2）：143-144.
[23] 张丽，李静，张娟，等.针刺联合中医情志干预治疗重症监护室患者并发压疮及便秘的疗效观察[J].长春中医药大学学报，2020，36（5）：1052-1055.
[24] 王振楠，李景新，杨蕾，等.浅析天枢穴[J].名医，2018（4）：32-33.
[25] 肖政华，谭芊任，崔峻松，等.慢性应激对小鼠胃肠运动及血清GAS、MTL的影响[J].贵阳中医学院学报，2018， 40（1）：23-26，54.