Abstract:Objective To investigate the clinical efficacy of endoscopic posterior lumbar interbody fusion for treatment of single-level lumbardegenerative disease. Methods The clinical data of 48 patients of single segment lumbar degenerative diseases treated in Baoji Hospital of Traditional Chinese Medicine from May 2018 to January 2021 were retrospectively analyzed. They were divided into minimally invasive group and open group according to different surgical methods, with 24 cases in each group. The minimally invasive group was treated with endoscopic posterior lumbar interbody fusion, and the open group was treated with traditional posterior lumbar fusion. The perioperative indexes, visual analogue scale (VAS) score of low back pain and Oswestry dysfunction index (ODI) were compared between the two groups. The clinical efficacy was evaluated according to the scoring standard of low back pain surgery in the spine group of Chinese orthopaedic society. Results The incision length of the minimally invasive group was shorter than that of the open group, the operation time was longer than that of the open group, the blood loss was less than that of the open group, and the length of hospital stay was shorter in the open group, and the differences were statistically significant (P < 0.05). Intra-group comparison: there were statistically significant differences between the two groups at each time point (P < 0.05). Comparison between groups: there were no significant differences in VAS score and ODI index between the two groups before operation (P > 0.05), and the VAS score and ODI index of the micro-wound group were lower than those of the open group at one week after operation (P < 0.05). However, there were no significant differences in VAS score and ODI index between the two groups at six months after operation and at the last follow-up (P > 0.05). There was no significant difference in clinical efficacy between the two groups (P > 0.05). Conclusion Endoscopic lumbar decompression and interbody fusion technology for the treatment of single level lumbar degenerative diseases has the advantages of small tissue trauma, less surgical bleeding, short hospital stay, fast postoperative recovery, and less damage to the posterior structure of the lumbar spine. At the same time, it can achieve similar curative effects to traditional open surgery.