Abstract：Objective To explore the relationship of serum lipid level and lipid combine index (LCI) with wheezing diseases in children. Methods A total of 6 311 children hospitalized in the Department of Pediatrics, Changzhou Second People’s Hospital Affiliated to Nanjing Medical University from July 2016 to June 2021 were selected for blood lipid analysis. The children were divided into wheezing group (1 707 cases) and non-wheezing group (4 604 cases) according to whether they had wheezing symptoms or signs at admission; according to body mass index (BMI), the children were divided into overweight-obese wheezing group (466 cases) and overweight-obese non-wheezing group (722 cases). The general data and blood lipid indexes of the children were collected, and LCI was calculated; the correlation between serum lipid level, LCI and asthmatic diseases in children were analyzed. Results There were significant differences in gender, age, BMI, previous history of asthma, breastfeeding alone, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol, high density lipoprotein cholesterol (HDL-C), and LCI between wheezing group and non-wheezing group (P ＜ 0.05). Gender, age, BMI, previous history of asthma, and TC were the influencing factors of asthmatic diseases in children (P ＜ 0.05). There were significant differences in gender, age, BMI, previous history of asthma, TC, TG, HDL-C, and LCI between overweight-obese wheezing group and overweight-obese non-wheezing group (P ＜ 0.05). Gender, age, previous history of asthma, TC, TG, and LCI were the influencing factors of asthmatic diseases in overweight-obese children (P ＜ 0.05). Conclusion Lipid levels is associated with wheezing in children, but not with LCI.
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