Research progress of the mechanism of drug resistance and detection methods of Mycobacterium tuberculosis
SONG Jing CHE Nanying
Department of Pathology, Beijing Chest Hospital, Capital Medical University Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing 101149, China
Abstract：This article reviews the mechanism and detection methods of drug resistance in Mycobacterium tuberculosis（MTB）. The mechanism of drug resistance is divided into intrinsic resistance mechanism of cell wall permeability reduction and efflux pump action and acquired resistance mechanism of target gene mutation. With the development of molecular biology techniques, mutations in target genes are considered to be the main mechanism of drug resistance for MTB. The main detection methods for drug resistance are phenotypic susceptibility testing and molecular susceptibility testing. The phenotypic assay method is used as the golden standard, but the detection period is long, while gene mutation detection can be completed within a few hours, so there is a better application prospect in the diagnosis of tuberculosis. In this paper, the mechanism and detection methods of drug resistance in MTB are reviewed in order to provide some reference for the development of rapid molecular diagnostic tools and anti-tuberculosis drugs.
宋婧 车南颖. 结核分枝杆菌耐药机制和检测方法的研究进展[J]. 中国医药导报, 2018, 15(29): 29-34.
SONG Jing CHE Nanying. Research progress of the mechanism of drug resistance and detection methods of Mycobacterium tuberculosis. 中国医药导报, 2018, 15(29): 29-34.
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